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The Use of Estradiol Metabolites for Treatment of Obesity, Syndrome X, Heart Failure, Renal Dysfunction and Vascular Endothelial Dysfunction

詳細技術說明

None

*Abstract

Methods are provided for preventing or treating risk factors for cardiovascular disease in an individual, comprising administering a therapeutically effective amount of a composition comprising an estradiol metabolite to said individual. Such risk factors include obesity, the metabolic syndrome, diabetes mellitus, vascular disorders, and renal disorders. Preferred estradiol metabolites include 2-methoxyestradiol, 4-methoxyestradiol, 2-hydroxyestradiol, and 4-hydroxyestradiol or prodrugs thereof. The compositions may also be in the form of a controlled release formulation. Methods are also provided for use of estradiol metabolites to treat or prevent insulin resistance, vascular endothelial dysfunction, hyperlipidemia, hypertension, diabetic nephropathy, proteinuria and reducing leptin levels. In addition, the methods provide a method of stabilizing glucose levels. These treatments may be used in either gender because of their lack of a feminizing estrogenic effect.

*Principal Investigation

Name: Raghvendra Dubey, Assistant Professor of Medicine

Department: Med-Pharmacology and Chemical Biology

Name: Edwin Jackson, Professor of Pharmacology and Medicine

Department: Med-Pharmacology and Chemical Biology

Name: Stevan Tofovic, Assistant Professor

Department: Med-Medicine

國家/地區

美國