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Quantitative X Chromosome Inactivation for the Diagnostic Evaluation of Women with Recurrent Spontaneous Abortion

*Abstract: A screening test to identify women carrying a lethal genetic trait that predisposes to recurrent spontaneous pregnancy loss. The test method involves the quantitative determination of the frequency of highly skewed X chromosome inactivation in DNA derived from tissue cells of female patients, relative to appropriate normal control women. "Highly skewed" is defined as preferential use of one chromosome in at least 90% of the patient's cells being tested. Suitable test tissues include, but are not limited to, peripheral leukocytes, oral mucosal cells, and biopsy material.

*Principal Investigation: Name: Eric Hoffman, Adjunct Professor
Department: Med-Microbiology and Molecular Genetics

Name: William Hogge
Department: Med-OB-Gyn & Reproductive Science

Name: Mark Lanasa, Student
Department: Med-Microbiology and Molecular Genetics

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