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A-21 Effective Method to Produce Multipotential Stem Cells from Adipose Tissues

技術優勢

ΓùÅ Patient-Friendly: Cells are harvested from adipose tissues, not from bone marrow.ΓùÅ Wide Application: It will introduce various treatment applications.ΓùÅ Easy and Efficient: SVF is collected by centrifugation and is resistant to freeze and thaw.

技術應用

ΓùÅ Treatment for ischemia disease, renal dysfunction, wounds, kidney disorders, and osteoporosisΓùÅ Research tool for regenerative medicine

詳細技術說明

None

*Abstract

Researchers at Nagoya University have developed an effective method to collect and produce large amounts of multipotential stem cells (MSCs) derived from human adipose tissues. These cells were introduced into ischemia disease, renal dysfunction, wound, kidney disorder, and osteoporosis mouse models, where they showed significant improvements of their symptoms. Because bone marrow contains very limited MSCs, using adipose tissues for regenerative medicine is recently getting more attentions. In this invention, MSCs are collected as stromal vascualr fractions (SVF) from adipose tissues by centrifugation. This fraction contains MSCs and other cells, such as endothelial and erythroid cells. Isolated cells are incubated in a lower serum medium with FGF-2 which selectively induce cell growth of MSCs.

附加資料

Inventor: OZAKI, Takenori | YASUDA, Kaoru | MARUYAMA, Shouichi | YAMAMOTO, Tokunori | GOTOH, Momokazu | MATSUO, Seiichi | KITAGAWA, Yasuo
Priority Number: WO2008018450A1
IPC Current: A61K003512 | A61P000910 | A61P001312 | A61P001702 | C12N000502
Assignee Applicant: National University Corporation Nagoya University
Title: CELL PREPARATION CONTAINING MULTIPOTENTIAL STEM CELLS ORIGINATING IN FAT TISSUE | PRÉPARATION CELLULAIRE CONTENANT DES CELLULES SOUCHES MULTIPOTENTES PROVENANT D'UN TISSU ADIPEUX
Usefulness: CELL PREPARATION CONTAINING MULTIPOTENTIAL STEM CELLS ORIGINATING IN FAT TISSUE | PRÉPARATION CELLULAIRE CONTENANT DES CELLULES SOUCHES MULTIPOTENTES PROVENANT D'UN TISSU ADIPEUX
Summary: The cell formulation is useful for treating ischemic disease, renal dysfunction, wound, urinary incontinence or osteoporosis. Use of pluripotent stem cell from fat tissue and sedimented cell population for manufacturing cell formulation (claimed).
Novelty: Cell formulation useful for treating ischemic disease, renal dysfunction, wound, urinary incontinence or osteoporosis, contains pluripotent stem cells derived from fat tissue

主要類別

生物醫學

細分類別

生物工程

國家/地區

美國