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Calcitonin Gene-Related Peptide For The Reduction Of Allergen-Induced Airway Hyperresponsiveness

技術優勢

Treatment of AHR

技術應用

Treatment of AHR

詳細技術說明

Administration of CGRP to sensitized and challenged mice resulted in the normalization of AHR.This potential therapy for AHR was tested in phase II of clinical trials however the trial was never completed.

*Abstract

Calcitonin gene-related peptide (CGRP) is a sensory neuropeptide which expression is reduced after allergen challenge in sensitized mice. The same mice develop eosinophilic airway inflammation and airway hyperresponsiveness (AHR). Scientists at National Jewish Health have shown that administration of CGRP to sensitized and challenged mice resulted in the normalization of AHR.

*Principal Investigation

Name: Erwin Gelfand, Chairman

Department: Department of Pediatrics

附加資料

Inventor: Cadieux, Alain
Priority Number: US6743429B2
IPC Current: A61K003823
US Class: 4241981 | 5140119 | 514826 | 514012
Assignee Applicant: Sherbrooke University,Quebec
Title: Use of calcitonin gene-related peptide in the prevention and alleviation of asthma and related bronchospastic pulmonary diseases
Usefulness: Use of calcitonin gene-related peptide in the prevention and alleviation of asthma and related bronchospastic pulmonary diseases
Summary: CGRP and its natural homolog (their fragments, analogs or derivatives) are useful for the prevention or alleviation of asthma, bronchospastic disease characterized by airway hyperreactivity or lung inflammatory reaction characterized by increased eosinophilia (claimed).
Novelty: Use of calcitonin gene-related peptide for preventing, reducing and/or alleviating bronchospastic airway diseases, especially reversible airway hyperreactivity and lung inflammation encountered in asthma

主要類別

生物醫學

細分類別

醫藥成分

國家/地區

美國