A mTOR-independent Activator of TFEB for Autophagy Enhancement and Uses thereof
A mTOR-independent Activator of TFEB for Autophagy Enhancement and Uses thereof
This invention relates to a composition comprising an autophagy enhancement compound. In particular, the present invention relates to a composition comprising a small molecule being able to enhance autophagy and lysosome biogenesis by activating the gene TFEB which can prevent the accumulation of toxic protein aggregates in treating neurodegenerative diseases such as Parkinson's, Alzheimer's and Huntington's diseases.
Prevent the accumulation of toxic protein aggregates in treating neurodegenerative diseases
1) 6 March 2015 (CN)
2) 6 March 2015 (EP)
3) 6 March 2015 (PT)
4) 30 January 2015 (US non -provisional)
5) 16 March 2016 (US non-provisional)
1) CN 201580012376.7
2) EP 15759224.7
3) PCT/CN2015/073764
4) US 14/609,438
5) US 15/071,222
A small molecule being able to enhance autophagy and lysosome biogenesis by activating the gene TFEB
