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Portable Ultrasonic Palpation System

總結: A portable ultrasound palpation device for measuring the Young's modulus and the thickness of a soft tissue layer includes a hand-holdable palpation probe having an ultrasonic transceiver connected in series with a load cell. During a test, the probe is placed on the tissue surface with a bony substratum. As the operator manually loads and unloads the probe on the tissue surface, a program embedded in a microprocessor module continuously causes the ultrasound emitter to emit ultrasound pulses into the soft tissue. The ultrasound echo signal reflected from the bony interface is received and its flight time is used by the program to calculate the original thickness and the deformation of the soft tissue. The corresponding load applied to the tissue is continuously recorded by the load cell, its driver, and amplifier module, and the data collection module. After collecting the data for a preset number of loading-unloading cycles, the program computes the Young's modulus of

附加資料: Patent Number: CN101072764B
Application Number: CN200580035478A
Inventor: KAZI, ASLAMUZZAMAN | CHEN, De-heng | KUHN, DEBORAH JOYCE | DOU, Qing-ping | LIN, Hui-xia | LANDIS-PIWOWAR, KRISTIN R | WAN, Sheng-biao | ZHOU, Ming-xiang
Priority Date: 19 Aug 2004
Priority Number: CN101072764B
Application Date: 15 Aug 2005
Publication Date: 10 Jul 2013
IPC Current: C07D031162 | A61P003500
Assignee Applicant: University of South Florida | Mcgill University | Wisconsin Alumni Res Found | The Hong Kong University of Science and Technology
Title: (-)-epigallocatechin gallate derivatives for inhibiting proteasome
Usefulness: (-)-epigallocatechin gallate derivatives for inhibiting proteasome
Summary: Compounds (I) are used as medicaments to reduce tumor cell growth (claimed). Treated breast cancer (MCF-7) cells were treated with compounds (I) for 24 hours, followed by MTT analysis to determine their effects on cell proliferation. Compound (2S,3R)-trans-5,7-bis(acetyloxy)-2-[3,4,5-tris(acetyloxy)phenyl]chroman-3-yl-3-(acetyloxy)benzoate caused 70% inhibition at 25 μM.
Novelty: New chromanyl ester derivatives, are proteasome inhibitors used to reduce tumor cell growth

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