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Method of Extracting Neural Stem Cells Using Nanoparticles

總結: This invention relates to a method of extracting biological cells from a subject, particularly, but not exclusively, a method of extracting neural stem cells from a living subject.

技術應用: This technology though in an early stage of development, may give exciting potentials in biological and clinical applications, particularly in the area of regenerative medicinal treatment, from bench to bed.

詳細技術說明: A method of extracting neural stem cells from a living subject, comprising the steps of introducing magnetic nanoparticles into the subject, targeting the neural stem cells with the magnetic nanoparticles to form magnetic nanoparticle-targeted cells, isolating the magnetic nanoparticle-targeted cells, extracting the magnetic nanoparticles-targeted cells from the subject.

附加資料: Inventor: CHEAH, Songeng, Kathryn | ZHANG, Linchyngjian, Janet
Priority Number: WO2006010323A1
IPC Current: C12N000500
Assignee Applicant: The University of Hong Kong
Title: PROCOLLAGEN IIA DEFICIENT MICE | SOURIS DEFICIENTE EN PROCOLAGENE IIA
Usefulness: PROCOLLAGEN IIA DEFICIENT MICE | SOURIS DEFICIENTE EN PROCOLAGENE IIA
Summary: (M1) is useful for producing mutant Col2A-1 transgenic mouse. (M2) is useful for producing a mutant mouse. (I) is useful for screening agents for treatment of a selected cardiac disorder, where the selected cardiac disorders include sudden cardiac death, cardiomegaly, cardiomyocyte, hypertrophy, cellular disarray, pulmonary hypertension with right ventricular hypertrophy, and valvular fibrosis (all claimed). (M1) is useful for screening potential drugs against ventricular remodeling, malignant arrhythmias, and congenital heart disease.
Novelty: Producing mutant procollagen IIA (Col2A-1) transgenic mouse, by introducing selected mouse embryonic stem cells having mutant Col2A-1 transgene into mouse blastocysts, and crossing chimeric founder transgenic mouse with wild-type mouse

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