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Hemiterpene Glycosides with Anti-platelet Aggregation Activities from Ilex Pubescens

總結: This serves for the purpose of improving mini-circulation, lower blood pressure, inhibit platelet aggregation, prevent thrombus, reduce cardiac ischemia, decline the excitation of the cardiac conduction system and enhance the ability of anoxia resistance of body. Two hitherto unreported novel hemiterpene glycosides were isolated in substantially pure form from the root of Ilex pubescens known as “Mao-Dong-Qing”. The chemical structures and some properties of these hemiterpenes have been elucidated. These hemiterpene glycosides possess anti-platelet aggregation activity more potent than those of salvianolic acid B and aspirin and may be used in pharmaceutical compositions in humans and mammals in need of such treatment.

技術優勢: Improve mini-circulation, lower blood pressure, inhibit platelet aggregation, prevent thrombus, reduce cardiac ischemia, decline the excitation of the cardiac conduction system and enhance the ability of anoxia resistance of body

技術應用: Treat cardiovascular diseases and hypercholestaemia, improve mini-circulation, lower blood pressure, inhibit platelet aggregation, prevent thrombus, reduce cardiac ischemia, decline the excitation of the cardiac conduction system and enhance the ability of anoxia resistance of body

詳細技術說明: Two hitherto unreported novel hemiterpene glycosides were isolated in substantially pure form from the root of Ilex pubescens. The chemical structure and some properties of these hemiterpene glycosides have been elucidated and are named pubescenoside A and pubescenoside B by the inventors. These hemiterpene glycosides possess anti-platelet aggregation activity more potent than those of salvianolic acid B and aspirin and may be used either alone or in combination in pharmaceutical compositions in humans and mammals in need of such treatment.

附加資料: Patent Number: US7419960B2
Application Number: US200531415A
Inventor: Liu, Liang | Jiang, Zhihong | Li, Min | Wang, Jingrong | Liu, Zhongqiu
Priority Date: 7 Jan 2005
Priority Number: US7419960B2
Application Date: 7 Jan 2005
Publication Date: 2 Sep 2008
IPC Current: A01N004304 | A61K003170 | C07H001500
US Class: 514025 | 5360041 | 5360182
Assignee Applicant: Hong Kong Baptist University
Title: Hemiterpene glycosides with anti-platelet aggregation activities from Ilex pubescens
Usefulness: Hemiterpene glycosides with anti-platelet aggregation activities from Ilex pubescens
Summary: For treating bleeding disorder (e.g. platelet activation and aggregation) in mammal (claimed).
Novelty: New pure hemiterpene glycoside compounds having an aglycone of a chemical formula 2-methylene-butane-1,3,4-triol and acylated by caffeic acid useful for treating bleeding disorder e.g. platelet activation and aggregation

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