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Imaging Beta-Amyloid Peptides and Inhibition of Beta-Amyloid Peptide Aggregation

總結: This can serve as a detection or monitor of therapeutic treatment of neurodegenerative disease, especially for Alzheimer's disease. It introduces methods of using carbazole-based fluorophores for labelling, imaging and detecting beta amyloid peptides, oligomers, and fibrils that fluoresce strongly upon binding in vitro or in vivo. Also, using these fluorophores that are non-toxic and able to cross the blood brain barrier is for inhibiting the growth of beta amyloid oligomers and preventing their aggregation upon binding in vitro or in vivo. It could potentially serve as Alzheimer's disease therapeutics and/or preventive agents. These fluorophores can potentially be developed into beta-amyloid peptide-specific MRI contrast agents.

技術應用: Detect or Monitor therapeutic treatment of neurodegenerative diseases, e.g. Alzheimer's disease

詳細技術說明: It gives new design of functional carbazole-based fluorophores for imaging and inhibition the aggregation of Aβ peptides. The imaging agents that can specifically bind Aβ fibrils and plaques in vitro and in vivo are of paramount importance for studying the pathological events of the disease, disease diagnosis and monitoring of therapeutic treatment.

附加資料: Patent Number: US9156814B2
Application Number: US13447127A
Inventor: Yang, Wanggui | Wong, Yi | Ng, Olivia T. W. | Li, Hung Wing | Yung, Ken K. L. | Kwong, Daniel W. J. | Wong, Ricky M. S.
Priority Date: 21 Apr 2011
Priority Number: US9156814B2
Application Date: 13 Apr 2012
Publication Date: 13 Oct 2015
IPC Current: A61K004910 | A61K00314439 | A61K00314709 | A61K0031473 | A61K004900 | A61K004908 | C07D040106
US Class: 1001
Assignee Applicant: Hong Kong Baptist University
Title: Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation
Usefulness: Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation
Summary: For labeling, imaging and detecting beta-amyloid peptides, oligomers and fibrils using carbazole-based fluorophores; and for treatment and prevention of beta-amyloid peptides aggregation-associated diseases (claimed) including neurodegenerative disease and Alzheimer's disease.
Novelty: Labeling, imaging and detecting beta-amyloid peptides, oligomers and fibrils useful for the treatment or prevention of neurodegenerative disease and Alzheimer's disease using carbazole-based fluorophores

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