亞洲知識產權資訊網為知識產權業界提供一個一站式網上交易平台，協助業界發掘知識產權貿易商機，並與環球知識產權業界建立聯繫。無論你是知識產權擁有者正在出售您的知識產權，或是製造商需要購買技術以提高操作效能，又或是知識產權配套服務供應商，你將會從本網站發掘到有用的知識產權貿易資訊。

返回搜索結果

β淀粉样肽的成像及β淀粉样肽的聚集的抑制

總結: This can serve as a detection or monitor of therapeutic treatment of neurodegenerative disease, especially for Alzheimer's disease. It introduces methods of using carbazole-based fluorophores for labelling, imaging and detecting beta amyloid peptides, oligomers, and fibrils that fluoresce strongly upon binding in vitro or in vivo. Also, using these fluorophores that are non-toxic and able to cross the blood brain barrier is for inhibiting the growth of beta amyloid oligomers and preventing their aggregation upon binding in vitro or in vivo. It could potentially serve as Alzheimer's disease therapeutics and/or preventive agents. These fluorophores can potentially be developed into beta-amyloid peptide-specific MRI contrast agents.

技術應用: Detect or Monitor therapeutic treatment of neurodegenerative diseases, e.g. Alzheimer's disease

詳細技術說明: It gives new design of functional carbazole-based fluorophores for imaging and inhibition the aggregation of Aβ peptides. The imaging agents that can specifically bind Aβ fibrils and plaques in vitro and in vivo are of paramount importance for studying the pathological events of the disease, disease diagnosis and monitoring of therapeutic treatment.

附加資料: Patent Number: CN102743769A
Application Number: CN201210119357A
Inventor: HUANG, Wen-cheng | HUANG, Yi | LI, Hong-rong | KUANG, Wei-zheng | WENG, Jian-lin | WU, Zhi-hua | YANG, Wang-gui
Priority Date: 21 Apr 2011
Priority Number: CN102743769A
Application Date: 20 Apr 2012
Publication Date: 24 Oct 2012
IPC Current: A61K004910 | A61K00314709 | A61K0031473 | A61K004100 | A61P002528 | C07D040106
Assignee Applicant: Hong Kong Baptist University
Title: Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation | Imaging of Beta-amyloid peptide and inhibition of Beta-amyloid Peptide aggregation
Usefulness: Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation | Imaging of Beta-amyloid peptide and inhibition of Beta-amyloid Peptide aggregation
Summary: For labeling, imaging and detecting beta-amyloid peptides, oligomers and fibrils using carbazole-based fluorophores; and for treatment and prevention of beta-amyloid peptides aggregation-associated diseases (claimed) including neurodegenerative disease and Alzheimer's disease.
Novelty: Labeling, imaging and detecting beta-amyloid peptides, oligomers and fibrils useful for the treatment or prevention of neurodegenerative disease and Alzheimer's disease using carbazole-based fluorophores

欲了解更多信息，請點擊這裡