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Collagen-Based Microspheres And Methods Of Preparation And Uses Thereof

總結

A Method Of Manufacture Of Ecm Microparticles Incorporating Bioactive Molecules For Drug Delivery Has Been Developed, Using A Modified Emulsification Method Or A Water-In-Oil-Phase-Separation Method. The Microspheres Are Photochemically Crosslinked To Control The Release Of The Bioactive Molecules For Better Drug Delivery Usage Without Compromising The Biocompatibility Of The Crosslinked Structures. The Method Uses Mild Fabrication Conditions And Simple Processes, No Toxic Chemical Crosslinking Reagent, Which May Cause Cytotoxicity And Calcification After Implantation, No Organic Solvents, Which May Reduce Drug Availability And Bioactivity, And No Vigorous Stirring Action, Which May Fragmentize Material With Poor Shape And Mechanical Stability And Thus Destabilize The Emulsion.; The Resulting Microparticles Or Microspheres Are Of Controlled Size, Controlled Release, Highly Biocompatible, And Useful For Drug Delivery As Well As Cell Culture.

附加資料

Patent Number: US7931918B2
Application Number: US2008166670A
Inventor: Chan, Barbara Pui | Chan, Ming Cheuk | So, Kwok Fai
Priority Date: 14 Sep 2004
Priority Number: US7931918B2
Application Date: 2 Jul 2008
Publication Date: 26 Apr 2011
IPC Current: A61K000916
US Class: 424499 | 424489
Assignee Applicant: The University of Hong Kong
Title: Collagen-based microspheres and methods of preparation and uses thereof
Usefulness: Collagen-based microspheres and methods of preparation and uses thereof
Summary: The method is for preparing natural extracellular matrix-based microspheres or population of microspheres for forming into structures for use in tissue engineering (claimed), and useful for drug delivery as well as cell culture i.e. three dimensional cell culture and implantation. The microspheres or microparticles can be formed into additional structures as coatings, encapsulated, or incorporated into other materials that act as binders, e.g. for use as tissue engineering matrices.
Novelty: Preparation of natural extracellular matrix-based microspheres by initiating sol-gel transition of natural extracellular matrix components, decelerating sol-gel transition, forming water-in-oil emulsion, and accelerating sol-gel transition

主要類別

生物醫學

細分類別

DNA /基因工程

申請號碼

US2008166670A

國家/地區

香港