Dna Encoding Mutated Collagen X
This Invention Provides An Isolated Dna Comprising The Sequence Which Codes For A Mutated Collagen X Or A Portion Thereof Wherein The Expression Of Said Dna Regulates Bone Growth. This Invention Provides A Polypeptide Encoded By The Isolated Dna Comprising The Sequence Which Codes For A Mutated Collagen X Or A Portion Thereof Wherein The Expression Of Said Dna Regulates Bone Growth. This Invention Also Provides A Polypeptide Which Comprise The Portion Of The Mutated Collagen X Capable Of Regulating Bone Growth. This Invention Further Provides A Transgenic Animal Comprising An Isolated Dna Comprising The Sequence Which Codes For A Mutated Collagen X Or A Portion Thereof Wherein The Expression Of Said Dna Regulates Bone Growth.
Patent Number: US6828433B2
Application Number: US2001975607A
Inventor: Cheah, Kathryn S. E. | Cheung, Kenneth M. C.
Priority Date: 8 Oct 1998
Priority Number: US6828433B2
Application Date: 11 Oct 2001
Publication Date: 7 Dec 2004
IPC Current: A01K0067027 | C07K001478 | C12N001512 | C12N001585 | A61K003800 | A61K004800
US Class: 5360231 | 4352521 | 4353201 | 435325 | 435455
Assignee Applicant: The University of Hong Kong
Title: DNA encoding mutated collagen X
Usefulness: DNA encoding mutated collagen X
Summary: (IIIa) or (I) is useful for treating a subject afflicted with dwarfism (effective to reverse dwarfism) and for treating a subject with low bone mass (which causes osteoporosis). (IIIa) and (I) are useful for improving the quality and speed of bone union after fracture (all claimed). (I) is useful for obtaining transgenic animal, preferably mouse, comprising (I).
Novelty: Col10-13del DNA encoding mutated collagen X polypeptide, useful for treating a subject afflicted with dwarfism, osteoporosis and for improving speed of bone union after fracture
生物醫學
DNA /基因工程
香港
