Novel Human Virus Causing Severe Acute Respiratory Syndrome (SARS) and Uses Thereof
The present invention relates to an isolated novel virus causing Severe Acute Respiratory Syndrome (SARS) in humans ("hSARS virus"). The hSARS virus is identified to be morphologically and phylogenetically similar to known member of Coronaviridae. The present invention provides the complete genomic sequence of the hSARS virus. Furthermore, the invention provides the nucleic acids and peptides encoded by and/or derived from the hSARS virus and their use in diagnostic methods and therapeutic methods, including vaccines. In addition, the invention provides chimeric or recombinant viruses encoded by said nucleotide sequences and antibodies immunospecific to the polypeptides encoded by the nucleotide sequences.
Inventor: Kwokhung Chan | Yi Guan | Frederick C. Leung | John Malcolm Nicholls | Joseph Sriyal Malik Peiris | Litman Poon | Kwokyung Yuen
Priority Number: CN100543132C
IPC Current: C12N000700
Assignee Applicant: The University of Hong Kong
Title: A novel human virus causing severe acute respiratory syndrome (SARS) and uses thereof | Induce severe acute respiratory syndrome (SARS) of new human virus and its application
Usefulness: A novel human virus causing severe acute respiratory syndrome (SARS) and uses thereof | Induce severe acute respiratory syndrome (SARS) of new human virus and its application
Summary: The hSARS virus, nucleic acids, and polypeptides are useful as vaccines for diagnosing or treating SARS. They are also useful in clinical and scientific research applications.
Novelty: New isolated human severe acute respiratory syndrome (hSARS) virus, useful as vaccine for diagnosing or treating SARS or in clinical and scientific research applications
生物醫學
病原
香港
