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ORAL DNA VACCINE COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTION

總結

The present invention provides an oral DNA composition for improving an impaired immunity associated with chronic infection of hepatitis B virus (HBV) comprising an attenuated strain of bacterial cells which preferentially target phagocytic cells of the intestin al mucosa, and which serve as a vehicle for a plasmid vector carrying one or more genes or complementary DNA coding for at least a portion of a hepatitis B viral protein or peptide. Giv en orally, the DNA composition causes a transient and self-limiting infection of the intestinal tract through autolysis of the bacterial cells and release of the plasmid after gaining entry into infected host cells. A promotor contained within the plasmid allows for expression of the HBV gene( s) in the eurokaryotic environment, the viral products of which help to booster a cell - mediated immunity to clear the infection and reverse a state of immune tolerance characteristi c of HBV chronic infection.

附加資料

Inventor: NG, MUN-HON | YUEN, KWOK-YUNG | ZHENG, BO-JIAN
Priority Number: CA2380471A1
IPC Current: A61K003929 | A61P000116 | C12N001551
Assignee Applicant: The University of Hong Kong
Title: ORAL DNA VACCINE COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTION | VACCIN ORAL A ADN POUR LE TRAITEMENT D'UNE INFECTION CHRONIQUE DUE AU VIRUS DE L'HEPATITE B
Usefulness: ORAL DNA VACCINE COMPOSITION FOR HEPATITIS B VIRUS CHRONIC INFECTION | VACCIN ORAL A ADN POUR LE TRAITEMENT D'UNE INFECTION CHRONIQUE DUE AU VIRUS DE L'HEPATITE B
Summary: The oral DNA composition is useful for inducing a cell-mediated immune response in a chronically infected HBV carrier and for suppressing transgene expression for a protracted period of time (claimed).
Novelty: New oral DNA composition comprising an attenuated strain of bacteria, useful for inducing a cell-mediated immune response in a chronically infected hepatitis B virus carrier and for suppressing transgene expression

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香港