Liver-Targeting Liposomal Doxorubicin Preparation for Treatment of Liver Cancer
Most of the cytotoxic drugs used in cancer chemotherapy have narrow chemotherapeutic utility and effectiveness and serious side effects at high dosages. As a result, drug delivery systems have been developed to modify the biodistribution of cytotoxic drugs, improving their selectivity for tumors or reducing the damage to normal tissues. This invention can further improve the performance of drug delivery systems.
Liposomes have been used extensively in delivery system for cytotoxic drugs used in cancer chemotherapy. Such use of liposomes as a drug delivery system has provided a means to improve the therapeutic utility of some conventional drugs. Since many liposomes are rapidly taken up by the cells of the mononuclear phagocyte system or reticuloendothelial system, they have been effective in delivering drugs to organs. However, their rapid clearance from the bloodstream has also limited their utility for transporting drugs to disease sites. Introduction of this new method overcomes this problem.
The novel invention provides compositions containing an effective amount of specific therapeutic agent encapsulated in a liposome coupled to a desialyated glycoprotein, e.g., desialyated glycoprotein-1. The new compositions can prolong the circulation of liposomes successfully.
1. Dosages of drugs can be reduced in the cancer treatment
2. Effective delivery of drugs to targeted organs
- Drug delivery and pharmacology
- Cancer chemotherapy
Patent Number: CN1262311C
Application Number: CN2001135792A
Inventor: WANG Z | ZENG R
Priority Date: 5 Apr 2001
Priority Number: CN1262311C
Application Date: 19 Oct 2001
Publication Date: 5 Jul 2006
IPC Current: A61K004742 | A61K0009127 | A61K00317052 | A61K003816 | A61P003500 | A61K004800
Assignee Applicant: The Hong Kong University of Science & Technology
Title: Medicinal composition for target direction transport curing cancer and its usage | Composition and pharmacy use used for targeting conveying medicament for the treatment of cancer
Usefulness: Medicinal composition for target direction transport curing cancer and its usage | Composition and pharmacy use used for targeting conveying medicament for the treatment of cancer
Summary: (C) is useful in the targeted delivery of a therapeutic agent to a tissue expressing asialoglycoprotein receptors. (C) is also useful for inhibiting the proliferation of liver cancer by administering to a subject in need of such therapy an effective amount of (C) containing doxorubicin encapsulated in desialyated glycoprotein-α1 coupled to a liposome (claimed). (C) is useful in cancer chemotherapy, in the manufacture of medicaments and for treating humans and other animals suffering from liver cancer.
診斷/治療
癌症/腫瘤
19 Oct 2001
Chinese 01135792.4
Chinese ZL01135792.4
TTC.PA.121
香港
