Health Care Product Containing Isoflavone Aglycones and Method of Producing the Same分離和純化具有高生物活性之大豆異黃酮的新方法
Isoflavones are a flavanoid subgroup found in a variety of plants with significantly high amounts in soybeans. According to an epidemiologic study, it showed that consumption of soybean isoflavones may be associated with the low incidence rates of some cancers, reduction in the risk of various diseases including cardiovascular problems, osteoporosis as well as menopausal symptoms. Interest in soy isoflavones has increased all over the world thereafter.
This invention is related to a novel method for producing isoflavones with high purities and high biological activities from soybeans. It includes three steps: (1) extraction of soybeans using organic solvent such as edible alcohol or methanol; (2) hydrolysis with acid; and (3) antisolvent crystallization. The procedure is very simple and can be easily adapted for a large-scale manufacture. The product by this method contains a high content (above 60%) of isoflavone aglycones determined by HPLC analysis and exhibits estrogenic activity on human cells. In short, the whole procedure of the invention is not only simple (three steps only) but also low-cost (without using chromatography column for separation).
The product can be widely applied in drugs or as additives for foods, beverages or cosmetics.
1. Simple method
2. Low manufacturing cost
3. Large-scale production
- Applied in drugs
- Additives for foods, beverages
- Cosmetics
Patent Number: US7553505B2
Application Number: US2007622468A
Inventor: Ng, Ka Ming | Luo, Qian | Zhang, Jingnan | Harjo, Benny
Priority Date: 12 Jan 2006
Priority Number: US7553505B2
Application Date: 12 Jan 2007
Publication Date: 30 Jun 2009
IPC Current: A61K003648
US Class: 424757
Assignee Applicant: The Hong Kong University of Science & Technology
Title: Health care product containing isoflavone aglycones and method of producing the same
Usefulness: Health care product containing isoflavone aglycones and method of producing the same
Summary: For extracting and purifying isoflavone aglycones (claimed) for relieving menopausal symptoms and other estrogen-deficient diseases, and in health care supplements or as additives for foods, beverages and cosmetics.
Novelty: Extracting isoflavone aglycone for treating menopausal symptom involves extracting flour of isoflavone material with solvent; converting isoflavone glucoside into aglycone by hydrolyzing with acid; and crystallizing with antisolvent
生物醫學
藥物
12 Jan 2007
US 11/622468
US 7553505
TTC.PA.286S
香港
