Aptamer D3P-21
- 总结
- Aptamer spezifisch für kastrationsresistenten Prostatakrebs.
- 技术优势
- High affinity Aptamer
Easy to produce
High plasma half-life
Excellent tumor selectivity
- 技术应用
- The Aptamer of the present invention may be used for diagnostic or therapeutic purposes. In particular when coupled to a drug, the Aptamer may be used in analogy to an antibody-drug-conjugate.
- 详细技术说明
- The inventors used an orthotopic xenograft mouse model to perform an in vivo selection in order to identify an aptamer that selectively binds to cells of a hormone refractory prostate tumour. Several rounds of selection starting from a DNA library yielded an aptamer that binds to tumour tissue in vivo and to PC3 cells in vitro. The Aptamer is characterized in a PEGylation pattern that stabilizes the Aptamer and prolongs plasma half-life.
- 合作类型
- Licensing
- 申请日期
- 21/01/2019 00:00:00
- 其他
- Patent application
- ID号码
- 5463
- 国家/地区
- 德国
欲了解更多信息，请点击 这里
