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CAR T-cells

总结

A human CD34 hinge region that allows detection as well as rapid CliniMACS-mediated enrichment of successfully engineered CAR-T cells.

技术优势

Rapid and easy staining for follow-up of CARs
Rapid and easy isolation of successfully engineered CAR T cells
Not susceptible to Fcg‑receptor binding
Modular composition enables other modifications in the hinge region

技术应用

therapeutic development

详细技术说明

For a large number of constructs, the hinge region consists of the CH2CH3 domain of a human IgG antibody, which can bindsto Fcg-receptors on macrophages and other cells thereby resulting in cross-activation and activation-induced cell death in vivo independent of recognition of the target antigen. The researchers in this invention haved replaced the CH2CH3 site by fragments of the human CD34 antigen that contain the epitope for the CD34 antibody QBEND10 that is used in the CliniMACS device sold by Miltenyi Biotech GmbH.

合作类型

Licensing

申请日期

08/09/2016 00:00:00

申请号码

EP20160187740 20160908

分类

- international:
C07K14/705; C07K14/725
- cooperative:
A61P35/02; C07K14/7051; C07K14/70517; C07K14/70521; C07K14/70535; C07K14/70578; C07K14/70596; C07K16/2878; C07K16/2896; C07K2317/53; C07K2317/622; C07K2319/00; C07K2319/02; C07K2319/03

其他

Patent application

ID号码

4813

国家/地区

德国