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Myocardial Viability Functional Assessment

详细技术说明

Late Gadolinium Enhancement Contrast ImagingA magnetic resonance imaging (MRI) method enables imaging with late gadolinium enhancement (LGE) contrast throughout the entire cardiac cycle with high temporal resolution. LGE, the clinical gold standard for assessing focal fibrosis/scars, depicts scar tissue as an enhancement 10-20 minutes after contrast injection. Contrast-agent accumulates in the scar-tissue due to diminished washout and can be visualized using a specific T1-weighted contrast that nulls the signal of the healthy myocardium, which contrasts with the bright scar tissue. However, this contains no information about the functional behavior.This technology allows assessment of scar tissue in multiple heart-phases and enables characterization of viability and functional properties of the heart simultaneously. The method involves two steps: 1) acquiring dynamic, semi-quantitative longitudinal relaxation maps through an initial inversion pulse and subsequent imaging, and 2) retrospectively synthesizing dynamic LGE images with a retrospectively chosen, virtual inversion time constant for all cardiac phases. The technique generates dynamic cardiac images depicting viability information in a functional manner (i.e., as a movie throughout the heartbeat).Dynamic Images Through Entire Cardiac CycleLGE images are commonly obtained with a single temporal snapshot of the cardiac cycle. However, single temporal snapshot images hamper joint assessment of temporal and functional evaluation of diseased tissue in the myocardium and are prone to misinterpretation in the presence of artifacts. So far, sequence improvements largely focus on improving the quality of the single diastolic temporal snapshots. This new method, however, generates dynamic LGE images depicting the heart in a temporally resolved manner throughout the entire cardiac cycle.BENEFITS AND FEATURES:Enables imaging with late gadolinium enhancement (LGE) contrastImages throughout the entire cardiac cycleHigh temporal resolutionAssesses scar tissue in multiple heart-phasesCharacterizes viability and functional properties of the heart simultaneouslyGenerates dynamic cardiac images depicting viability information in a functional manner (i.e., as a movie throughout the heartbeat)May shorten scan time and increase temporal resolutionAPPLICATIONS:Conventional MRI scannersFocal fibrosisMyocardial infarction/heart attack assessmentsMay use in-flow suppression to generate a black-blood contrastPhase of Development - Pilot scale demonstration

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国家/地区

美国