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Implantable Degradable mesh for soft and Hard Tissue Repair

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*Abstract

UNIVERSITY OF MISSOURIOffice of Technology Management and Industry RelationsNon-confidential Abstract of InventionUM Disclosure Number 17UMC118Title: Implantable Degradable Mesh for Soft and Hard Tissue RepairInnovation: Inventors at the University of Missouri have developed a novel technology by electrospinning a biodegradable polymer polycaprolactone (PCL), integrating an amphiphilic substance and a bioactive nanoparticle to create an implantable mesh that can be utilized for tissue engineering and grafting. Electrospun PCL is hydrophobic leaving a material that doesn’t integrate well into the body. Complete wetting of the electrospun PCL is achieved by integrating this amphiphilic substance leaving an increased surface energy on the material creating enhanced cellular attachment. Addition of a bioactive nanoparticle provides free radical protection and lowering the inflammatory potential.Background: The global soft tissue repair market was valued at around USD 11.15 billion in 2015 and is expected to reach approximately USD 17.12 billion by 2021, growing at a CAGR of around 7.5% between 2016 and 2021. This growth can be attributed to an increase in geriatric population coupled with rising healthcare expenditure, along with sports injuries. The increasing number of soft tissue injuries due to sports is further anticipated to fuel the market for soft tissue repair in the near future. By the addition of bioactive nanoparticles, this invention provides headway in the existing soft tissue repair industry. Applications:-Soft and hard tissue repair, especially grafts for osteoarthritis, post-traumatic osteoarthritis-Other areas- hernia repair, dural repair, vaginal sling procedure, skin repair, dental repair, and breast reconstruction repairAdvantages:-Addition of a bioactive nanoparticle lowers inflammatory reaction to the graft, thereby increasing efficacy. -In addition, different bioactive nanoparticles can be added to the mesh to induce different cellular responses. -The template is amendable for cell seeding as well.Patent status: PendingInventors:-Sheila Grant-Ferris Pfeiffer-Chris Glover-David Grant-Colten SniderFor more information contact:Brian Buntaine, Sr. Licensing & Business Development AssociateOffice of Technology Management and Industry RelationsEmail: buntaineb@missouri.eduPhone: 573-882-0470

*Principal Investigation

Name: Sheila Grant, Professor

Department:

Name: David Grant

Department:

Name: Ferris Pfeiffer, Assistant Professor

Department:

Name: Colten Snider, Graduate Research Assistant

Department:

Name: Chris Glover, Graduate Student/Researcher

Department:

其他

国家/地区

美国