Novel VSV-Based Vaccine Platform for Zika Virus
- 详细技术说明
- None
- *Abstract
-
There is currently no vaccine available for protecting against Zika virus (ZIKV) infection and disease. Researchers at Nationwide Children’s Hospital have developed multiple novel vaccine candidates using vesicular stomatitis virus (VSV) to express specific ZIKV proteins. VSV is a bovine virus that is partially attenuated in humans and has been used previously as a vaccine vector for other viruses, including a candidate vaccine for Ebola that has been successful in recent clinical trials. The protection conferred by these candidate ZIKV vaccines does not rely on antibodies against the ZIKV envelope proteins and thus eliminates concern of Antibody Dependent Enhancement or cross-reactivity with other species of flavivirus. These ZIKV candidate vaccines are highly attenuated yet induce an effective, protective immune response against ZIKV infection and disease in both a standard and a highly sensitive mouse model.
- *Inquiry
- Andrew CorrisThe Research Institute at Nationwide Children’s HospitalOffice of Technology Commercialization700 Children’s DriveColumbus, OH 43205T: (614) 355-1604 F: (614) 722-2716Andrew.Corris@nationwidechildrens.org
- *IP Issue Date
- None
- *IP Type
- Provisional
- 国家
- United States
- 申请号码
- 62/584,629
- 国家/地区
- 美国
