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DHAA and Derivatives for Treatment of BRAF-V600E-Positive Cancer

标题

Dehydroacetic (DHAA) Acid & Derivatives

详细技术说明

ApplicationHypolipidemic dehydroacetic acid (DHAA) treatment to prevent growth of BRAF V600E positive tumors.Key BenefitsTreatment with slows BRAF V600E-positive tumor growth.Repurposed compound may speed FDA approval.May be used in combination with other therapies.Market SummaryAccording to the American Cancer Society, skin cancer is the most common form of human cancer, and diagnosed cases continue to rise. Up to 50% of melanoma cases harbor the BRAF V600E mutation, which is also a contributing factor in other cancer types such as, colorectal cancer, hairy cell leukemia, and multiple myeloma. Treatment strategies for melanoma include surgical removal of the tumor and surrounding area followed by chemotherapy and immunotherapy. These therapies are often successful; however, some mutations associated with melanoma are sensitive to the patient’s diet. There is a need for therapeutic strategies that address these diet sensitive forms of melanoma.Technical SummaryBRAF is a serine/threonine- protein kinase and a proto-oncogene that promote cell growth by initiating the MAP kinase signaling cascade. BRAF V600E mutations are known to enhance the tumorigenicity of melanoma. Hypolipidemic agents, such as dehydroacetic acid (DHAA) competitively bind the BRAF V600E mutant protein without initiating the MAP kinase signaling cascade. Emory inventors demonstrated that DHAA significantly reduced tumor size in an animal model of melanoma without any observed toxicity. DHAA is currently used in cosmetics and as a food preservative and could be repurposed as a hypolipidemic for use in cancer therapeutics. DHAA has potential for use in other BRAF V600E positive forms of cancer.Developmental StageDHAA is a compound that has been tested in vitro and in vivo in a mouse model.Publications: Xia, S. et. al. (2017) Cell Metabolism, 25(2), pp358-373.

*Abstract

None

*Principal Investigation

Name: Jing Chen, Professor

Department: SOM: HMO: Hematology/Medical Oncology

Name: Jack Arbiser, Professor

Department: SOM: Dermatology: Admin

Name: Brian Pollack, Assistant Professor

Department: SOM: Dermatology: Admin

Name: Siyuan Xia, Postdoctoral Fellow

Department: SOM: HMO: Hematology

申请日期

Nov 6, 2017

国家/地区

美国