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New Oral Analgesic Formulation for Control of Pain in Dogs

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Description:  Researchers within theCollege of Veterinary Medicine at Kansas State University have discovered thatthe repurposing of two human approved drugs if administered orally to dogsprovides a long acting opioid effect that can be used for the control of mild tosevere acute and chronic pain.The optionsfor treating moderate to severe pain in dogs on an outpatient basis are verylimited. Nonsteroidal anti-inflammatory drugs have limited efficacy for mild tomoderate pain and can have adverse side effects including gastrointestinalulcerations and perforations, renal failure and death. Injectable opioids arefrequently used for inpatients, but are short acting (2-6 hours duration) andare not practical for most outpatients. Additionally, sending home injectableopioids with clients presents a risk for inadvertent drug exposure, misuse, anddiversion. Opioids administered orally to dogs do not work because the drugs arerapidly metabolized in the dog’s body before analgesia can take effect.  A FDA approved fentanyl transdermal solutionfor use in dogs was recently discontinued by the manufacturer and is no longeravailable.   Through several studiesanalyzing different drug combinations, Dr. KuKanich and his team discoveredthat if you combine oral methadone with a frequently used antifungal drug, fluconazole(at a very low dose), it increases oral bioavailability and opioid duration indogs.  Fluconazole acts as a drug inhibitor of a specific liverenzyme allowing methadone to remain active in the body longer.  Methadone plus fluconazole administered orallyproduced clinical opioid effects for 12 hours in dogs and twice daily dosingwill allow for excellent dosing compliance for both inpatients and outpatients.  These two drugs arerelatively inexpensive and can be formulated together into a tablet, capsule oran oral suspension for ease of use.  An inexpensive opioid antagonist could beincluded in the formulation to avoid intentional misuse and diversion by petowners.  This new technology couldprovide veterinarians and dog owners with a new option to treat acute painafter surgery or trauma and chronic pain at home.  It could also provide clinics with a newoption when pain relief for 12 hours is desirable, such as overnight. Advantages:Long-acting oral pain reliefInexpensiveEasy to administer for dog ownersApplications:  New oral analgesicproduct for pain relief in dogsFigure 1:Figure 1. Plasma methadone concentrations (mean ± SD) in 6 dogs/treatment administeredfluconazole 2.5 or 5 mg/kg PO q 12h with methadone 1 mg/kg administered 24hours after fluconazole or fluconazole 5 mg/kg PO q24h with methadone 1 mg/kgadministered 12 hours after fluconazole.PatentStatus: Provisional Patent Application filed in September 2017.Interested parties should contact:Kansas State University Institute for Commercialization (KSU-IC)2005 Research Park Circle Manhattan, KS 66502Tel: 785-532-3900 Fax: 785-532-3909E-Mail: ic@k-state.edu

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美国