A Bimodal Approach For Rapid And Quantitative Authentication of Medicines and Dietary Supplements
- 详细技术说明
- None
- *Abstract
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This technology integrates nuclear quadrupole resonance (NQR) and near-infrared (NIR) spectroscopic sensors to provide for rapid, low-cost, and quantitative analysis and authentication of medicines, dietary supplements and other compounds. The combination affords fast response time and quantitative chemical component analysis, which further enables significantimprovements over traditional approaches for verifying the contents of packaged medicines and supplements. The proposed devices are expected to have a broad range of applications, such as in personal healthcare, customs and border control, and food security to name a few.NQR is also a bulk method that is insensitive to packaging, coatings, and other surface conditions. In contrast, since the NIR measurement data may include a large number of overlapping lines, its database may be constructed using chemometric analysis, such as pattern recognition and machine learning.NIR is able to function as a preliminary filter on the unknown sample, narrowing down the range of categories in a short period of time. Then NQR can follow up and generate a more precise analysis, i.e., provide detailed information about the sample. Bothtechniques are low-cost, free of radiation and safety concerns, and easy to use with minimal training. Moreover, they can be integrated into portable devices. For example, the prototype system includes a miniaturized NIR spectrometer integrated with a miniature NQR spectrometer for rapid, accurate, and quantitative materials authentication.
- 国家/地区
- 美国
