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Cabergoline Analogs

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Cabergoline Analogs without 5-HT2B AgonismAnalogs of cabergoline have been developed that have little or no agonism to the 5-HT2B receptor. Specifically, the analogs incorporate two novel side chain modifications, which appear to bypass the negative side effects, cardiac valve regurgitation (CVR), of the parent molecule. This technology has the potential to be a safe and effective treatment for sexual dysfunction, without causing the harm associated with other sexual dysfunction medications.MN-IP Try and BuyThis technology is available via a standard negotiated license agreement. Contact Raj Udupa for specific details.Treatment for Parkinson’s Disease, Cushing’s Disease and Sexual DysfunctionCabergoline is a prescription drug used to lower levels of the prolactin hormone. Clinically, it is used to treat prolactinomas, Parkinson’s disease, Cushing’s disease, and male patients suffering from sexual dysfunction. However, clinical use decreased in 2007 when studies from the New England Journal of Medicine implicated cabergoline in causing cardiac valve regurgitation (CVR). This potentially fatal complication is associated with drugs that are 5-HT2B agonists. There exists a need for safe analogs of cabergoline that do not have this dangerous effect.BENEFITS AND FEATURES OF CABERGOLINE:Novel cabergoline side chain modifications bypass potentially fatal side effectsTreats patients suffering from male sexual dysfunction; lowers an elevated level of prolactin, which is a risk factor

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国家/地区

美国