Subunit vaccine for Poultry Infectious Bronchitis Virus (IBV)
Auburn University is seeking a licensee or a partner for further development of a subunit vaccine providing protection against infectious bronchitis virus (IBV) in poultry. IBV is highly prevalent in the poultry industry and causes millions of dollars in losses despite extensive vaccination with commercially available vaccines. Furthermore, studies indicates that current IBV live vaccines lead to new viruses that actually perpetuate IBV infection. This subunit vaccine provides robust protection without the complications associated with currently available live vaccines. Advantages· Easier and faster to develop for emerging serotypes than live attenuated vaccines· Will not change or produce outbreaks of disease· Potential for mass delivery via spray or in ovo, using viral vectors, nanoparticles, or appropriate adjuvantsStatus· Provisional patent application has been filed.· Tests in chickens showed better tissue attachment and reduced viral load & tissue damage· Studies ongoing/proposed for delivery using viral vectors or via mucosal/in ovo routes.
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