Murine Monoclonal Antibody to Murine CD36
- *Abstract
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CD36 is a major platelet glycoprotein also found on monocytes, macrophages and some endothelial cells. CD36 may play a role in cell adhesion as a receptor for thrombospondin. Absence of CD36 protects against the formation of arterial plaques thus slowing the development of atherosclerosis. CD-36 deficiency also leads to cardiomyopathy in mice. Investigators at the Weill Medical College of Cornell University have developed a murine anti-murine CD-36 IgA monoclonal antibody that reacts specifically with CD36 as determined by flow cytometry and immunoprecipitation. The immunogen used was a recombinant adenovirus vector containing the cDNA for murine CD36. This antibody will be useful in studying mouse models for angiogenesis, endothelial cell signaling, foam cell formation, phagocytosis, wound healing, inflammation, diabetes and energy metabolism. Research using the antibody is described in The Journal of Clinical Investigation, Vol. 105, No. 8: 1095-1108 (2000).
- *Licensing
- Vibhu Sachdev(212) 746-6187sachdev@cornell.edu
- 其他
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Differential roles of CD36 and alphavbeta5 integrinin photoreceptor phagocytosis by the retinal pigment epithelium. J. Exp. Med., 2001, 194,1289-98
- 国家/地区
- 美国
