A Transgenic Animal Inserted with Reporter Gene of Nerve Stem Cells and Neural Progenitor Cells
- *Abstract
-
This invention covers a transgenic mouse whose neural and pancreatic stem and progenitor cells are genetically tagged with GFP, which enables in vivo analysis of pluripotency and self-renewal activity of nerve stem and progenitor cells. The transgenic mouse contains a DNA construct consisting of a neural enhancer region, which is transcriptionally active only in neural stem and progenitor cells, driving the expression of the green fluorescent protein, GFP.
See also D-1997 for a patented FACS method for separating stem cells from a mixed population and D-2239, 2279, 2606, and 2862 for specific sorted cell populations.
- *Licensing
- Dan-Oscar Antsonda429@cornell.edu212-746-1297
- 其他
-
Kawaguchi A et al (2001) Nestin-EGFP transgenic mice: visualization of the self-renewal and multipotency of CNS stem cells. Mol Cell Neurosci. 17(2):259-73.
- 国家/地区
- 美国
