Diffusively Permeable Monolithic Biomaterial with Embedded Mircofluidic Channels
- 详细技术说明
- This technology improves wound healing by use of biomaterial embedded with microfluidic networks to allow for active management of the chemistry within the biological matter.
- *Abstract
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Each year, more than seven million Americans suffer severe acute or chronic cutaneous wounds, many of which cannot be effectively treated with available wound healing methods. An important improvement to the wound healing process would be the ability to deliver and extract reagents on the micrometer scale over the macroscopic dimensions of a typical wound. This type of wound healing would require that a micrometer-scale vascular network be manufactured directly into a porous, biocompatible material.
We present a new technology that accomplishes the above-described improvement to wound healing. Cornell’s Vascular Biomaterial (VB) has been embedded with microfluidic networks to allow for active management of the chemistry within the biological matter. The networks can act as an artificial vascular system for synthetic materials, and the VB has potential to act as a scaffold for the more efficient healing of chronic wounds.
Potential Applications
Micrometer-scale control of mass-transfer in biomaterials has the potential to impact work in many fields, including:
- Wound healing
- Tissue culture
- Tissue engineering
- Drug delivery
- Biological microfabrication
Advantages
Vascular Biomaterials offer unprecedented control of the chemical character of the interfaces between synthetic and biological systems. This ability to create artificial tissues that can be integrated into biological tissues addresses two important challenges in the field of wound healing:
1) Clinical treatment of severe cutaneous wounds due to burns or diabetes
2) In vitro modeling of the wound bed and the development of improved epidermal grafts
- *Licensing
- Carolyn A. Theodorecat42@cornell.edu(607) 254 4514
- 其他
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- Stroock AD and Cabodi M, Microfluidic Biomaterials, M.R.S. Bulletin, February 2006
- 国家/地区
- 美国
