Integration of Amino Acid-based Poly(ester amide)s with Aliphatic Polyesters
- 详细技术说明
- Theinvention integrates two types of materials, polyester amides (PEA) andabsorbable aliphatic polyesters (APE), to create a new family of biodegradablematerials with improved properties.
- *Abstract
-
PEAs are known for their enzymaticdegradation and good biological and elastomeric properties, while APEs aredegraded by hydrolytic mechanism and have a more rigid semi-crystallinestructure. Combining both material typesinto a single entity incorporates the merits of both types of biomaterials,resulting in improved degradation and mechanical properties as well as lowerinflammation.
Twodistinct block copolymer synthesis approaches were employed to integrate the materialtypes. The first approach involves PEAand APE materials located at different blocks, and the second incorporates APEmaterial into a segment of the PEA block.
PotentialApplications
- Various biomedical and biomaterials applications including surgical implants and devices, e.g. bone anchor, surgical mesh, wound closure, drug carriers, etc.
Advantages
- Highly biodegradable – can be degraded by enzymes and hydrolytically
- Improved mechanical properties
- Non-toxic and biocompatible
- *Licensing
- Martin Teschlmt439@cornell.edu(607) 254-4454
- 其他
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- Patent application: 14/342,144
- Kai Guo, C. C. Chu, Synthesis and characterization ofpoly(ε-caprolactone)-containing amino acid-based poly(ether ester amide)s,Journal of Applied Polymer Science (2011).
- 国家/地区
- 美国
