Inhibition Of Protein Tyrosine Phosphatase - Sigma For Hematopoietic Regeneration
- 技术优势
- 15 fold increase in hematologic recoveryApplicable for both white and red blood cell regenerationExtensively characterized mechanism of action
- 技术应用
- Treatment of patients undergoing hematopoietic cell transplantationTreatment of myelosuppressive chemotherapyTreatment of anemia caused by chronic kidney disease in patients on dialysis
- 详细技术说明
- UCLA researchers in the Departments of Medicine and Chemistry and Biochemistry have identified a novel receptor, Protein tyrosine phosphatase sigma (PTPS) expressed on hematopoitic stem cells. They have characterized the mechanism extensively in vivo by knockout studies and found that PTPS regulates HSC regeneration. Based on their discovery, they have developed novel inhibitors targeting PTPS that cause dramatic hematopoitic stem cell regeneration in mice models and significantly improve the life span in mice receiving fatal irradiation.
- *Abstract
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UCLA Researchers have identified a novel pharmacological target for hematopoietic stem cell regeneration. They have developed small molecule inhibitors against the target and shown that the inhibitors cause rapid stem cell regeneration.
- *Principal Investigation
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Name: John Chute
Department:
Name: Michael Jung
Department:
Name: Emelyne Diers
Department:
- 其他
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State Of Development
- Identification and validation of PTPS receptor by knockout studies in mice
- Inhibitors developed and tested in mice models
Background
Depletion of white and red blood cells also known as Myelosuppression is a common side effect of chemotherapy and radiotherapy. Currently, one FDA approved growth factor is used that increases white blood cell count but there are no therapies for total blood cell regeneration. Hematopoietic stem cells (HSCs) offer an alternative therapy, as they are a reservoir of both white and red blood cells. However, the mechanistic details of factors that govern HSC regeneration and proliferation are not known and no therapeutics that can increase HSC regeneration are available.
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Tech ID/UC Case
27473/2016-518-0
Related Cases
2016-518-0
- 国家/地区
- 美国
