Anti-Cspg4 Fusions with Type I Interferon for the Treatment of Malignancy
- 技术优势
- The fused anti-CSPG4/interferon has shown high efficacy in inhibiting the growth of melanoma cell lines in cell culture and in immunodeficient mice.
- 技术应用
- This technology can be used for treatment of a range of human cancers, including:MelanomaMultiple myelomaGliomaTriple-negative breast cancerChronic lymphocytic leukemia
- 详细技术说明
- UCLA researchers have developed antibody-IFN fusion proteins to selectively localize IFN at tumor sites. The fusion proteins were shown to inhibit the growth of melanoma cell lines in vitro and in vivo.
- *Abstract
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UCLA researchers have developed antibody-interferon fusion proteins that show high efficacy against cancer cells in vitro and in vivo.
- *Applications
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This technology can be used for treatment of a range of human cancers, including:
- *Principal Investigation
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Name: Sherie Morrison
Department:
Name: John Timmerman
Department:
Name: Kham (Ryan) Trinh
Department:
- 其他
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State Of Development
Significant pre-clinical data has been obtained. Background
Interferons (IFNs) are proteins made by the host cell in response to pathogens that are potent regulators of cell growth. In addition, IFNs possess inhibitory effects against many human cancers. However, since less than 0.01% of injected IFNα reaches the desired target tumor sites, the therapeutic cannot achieve effective concentrations at the tumor sites without also introducing significant systemic toxicity. Therefore, there exists an unmet need to develop antibodies to carry IFNs directly to cancer sites. Related Materials
Additional Technologies by these Inventors
- Vectors for the Recombinant Expression of Human Immunoglobulins
- Improved Rh (D) Human Blood Typing Reagent
- Antibody Fusion Proteins for Treating Cancer
- Hybrid IgA/IgG Polymeric Antibodies
- Production of Secretory IgA with Increased Stability
- Vectors for Antibody Expression
Tech ID/UC Case
24488/2013-718-0
Related Cases
2013-718-0
- 国家/地区
- 美国
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