Microfluidic Platform to Control Particle Placement and Spacing in Channel Flow
• High throughput with capabilities up to 1 m/s flow speed• Easy fabrication• Compact, no need for external control units• No limitations from material properties of particles
• Flow cytometry• Cell printing• Particle encapsulation• Metamaterial synthesis
Researchers from the Department of Bioengineering at UCLA have developed a microfluidic platform that controls particle-wall and particle-particle interactions by intertial flow, which leads to capability of manipulation of inter-particle spacing during solution exchange. This microfluidic platform utilizes expansion and contraction channel geometries to make particle distribution more uniform in Reynolds number flow. Moreover, particle-particle spacing can be tuned to a desired frequency. Unlike existing particle manipulation methods, particle manipulation by inertial flow gives extremely high-throughput without bulky external control units. The device fabrication is simple and easy, requiring PDMS molding and bonding only.
Patent Number: US20130233420A1
Application Number: US13988282A
Inventor: Di Carlo, Dino | Lee, Wonhee
Priority Date: 18 Nov 2010
Priority Number: US20130233420A1
Application Date: 17 May 2013
Publication Date: 12 Sep 2013
IPC Current: F17D000100
US Class: 13756501
Assignee Applicant: The Regents of the University of California
Title: PARTICLE FOCUSING SYSTEMS AND METHODS
Usefulness: PARTICLE FOCUSING SYSTEMS AND METHODS
Summary: The system such as dual-inlet co-flow system is useful for focusing and/or analyzing particles.
Novelty: System e.g. dual-inlet co-flow system for focusing and/or analyzing particles, comprises a first inlet, an inertial focusing microchannel disposed in a substrate and connected to the inlet, and a pressure/flow source
生物医学
医疗装置
20130233420
State Of Development Experiments and model simulations have been performed. Background Micro-scale particles in flow can be found in many fields of science and technology. One example is cells in blood stream. Control of particle motion/position in flow has numerous applications such as flow cytometry and particle encapsulation. Control of particle positions in particle laden flows is typically achieved by external force fields such as acoustic, electric, or magnetic fields. However, such methods consume power, require a bulky setup and efficiencies degrade with increasing flow rate, thus lowering the throughput. Recently, fluid inertia has been used to manipulate particle position in flow with high throughput in the transverse direction (particle-wall spacing), but not the lateral direction (particle-particle spacing). Although studies to date have provided simple descriptions of lateral spacing phenomena as a function of particle Reynolds number, the mechanisms of self-assembly in these systems are not well understood and have not been engineered effectively. Related Materials Dynamic self-assembly and control of microfluidic particle crystals. PNAS. (2010) Additional Technologies by these Inventors Tech ID/UC Case 23238/2011-038-0 Related Cases 2011-038-0
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