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Diagnostic Markers to Distinguish Between Squamous Cell Carcinoma and Pseudoepitheliomatous Hyperplasia

技术优势

Rapid: PCR based approach allows fast turnaround. Low-cost: Can be performed with standard clinical laboratory equipment. Accurate 96 percent of the time for predicting Squamous Cell Carcinoma & 90% for predicting Pseudoepitheliomatous Hyperplasia.

技术应用

Provides the scientific basis for a diagnostic kit that differentiates cutaneous squamous cell carcinoma from pseudoepitheliomatous hyperplasia in clinical samples. Provides methods for identifying specific genes as prognostic markers for cutaneous squamous cell carcinoma. Provides methods of using molecular pathways as targets for the treatment of cutaneous squamous cell carcinoma.

详细技术说明

UCLA scientists in the laboratory of Drs. Xinmin Li and Scott Binder of UCLA's Department of Pathology & Laboratory Medicine have developed a novel multiplex PCR-based test to distinguish between squamous cell carcinoma and pseudoepitheliomatous hyperplasia. The invention utilizes markers that have been identified through gene expression profile analysis of squamous cell carcinoma and pseudoepitheliomatous hyperplasia. This diagnostic test is rapid, cost-effective, and can replace the non-quantitative and subjective diagnostic methods currently used.

*Abstract

UCLA scientists have developed a novel diagnostic kit to reliably distinguish squamous cell carcinoma (SCC) from pseudoepitheliomatous hyperplasia (PEH). This fast diagnostic test can replace the non-quantitative and subjective diagnostic methods currently used in hospitals.

*Applications

• Provides the scientific basis for a diagnostic kit that differentiates cutaneous squamous cell carcinoma from pseudoepitheliomatous hyperplasia in clinical samples.
• Provides methods for identifying specific genes as prognostic markers for cutaneous squamous cell carcinoma.
• Provides methods of using molecular pathways as targets for the treatment of cutaneous squamous cell carcinoma.

*IP Issue Date

Mar 27, 2018

*Principal Investigation

Name: Scott Binder

Department:

Name: Xinmin Li

Department:

Name: Seong Ra

Department:

Name: Jian Zhou

Department:

附加资料

Patent Number: WO2013056042A1
Application Number: WO2012US59947A
Inventor: LI, XinMin | ZHOU, Jian | BINDER, Scott W. | RA, Seong
Priority Date: 14 Oct 2011
Priority Number: WO2013056042A1
Application Date: 12 Oct 2012
Publication Date: 18 Apr 2013
IPC Current: C12Q000168 | C12N001511
Assignee Applicant: The Regents of the University of California
Title: MULTIPLEX PCR-BASED TESTING OF CUTANEOUS SQUAMOUS CELL CARCINOMA AND PSEUDOEPITHELIOMATOUS HYPERPLASIA AND METHODS FOR DISTINGUISHING THE SAME | ANALYSE PAR PRC MULTIPLEXE DU CARCINOME ÉPIDERMOÏDE CUTANÉ ET DE L'HYPERPLASIE PSEUDOÉPITHÉLIOMATEUSE ET MÉTHO
Usefulness: MULTIPLEX PCR-BASED TESTING OF CUTANEOUS SQUAMOUS CELL CARCINOMA AND PSEUDOEPITHELIOMATOUS HYPERPLASIA AND METHODS FOR DISTINGUISHING THE SAME | ANALYSE PAR PRC MULTIPLEXE DU CARCINOME ÉPIDERMOÏDE CUTANÉ ET DE L'HYPERPLASIE PSEUDOÉPITHÉLIOMATEUSE ET MÉTHODES DE DISTINCTION DE CES DEUX AFFECTIONS
Summary: For differentiating/identifying cutaneous squamous cell carcinoma from pseudoepitheliomatous hyperplasia in a biological sample, where the sample is obtained from a human; for treating cutaneous squamous cell carcinoma.

主要类别

生物医学

细分类别

DNA /基因工程

申请号码

9926604

其他

State Of Development

The researchers have identified unique gene signatures to SCC and PEH. These signatures have been converted into a PCR-based assay and have been validate using 60 human specimens. A greater number of specimens is being tested to validate and refine the diagnostic power.

Background

Squamous cell carcinoma (SCC) is one of the most commonly diagnosed cutaneous cancers and affects over 250,000 people each year. The current diagnostic standard uses hematoxylin-eosin (HE) staining of tissue sections; however, this approach does reliably distinguish SCC from other skin conditions, including pseudoepitheliomatous hyperplasia (PEH). Even though the pathogenesis of these skin conditions is dissimilar, SCC and PEH can look virtually identical upon clinical and histological examination. Small tissue sample sizes, dense inflammation, and poor orientation add to the difficulty of distinguishing between these conditions with histological examination alone. Thus, a robust genetic test for accurately distinguishing between SCC and PEH will provide improved diagnoses and treatment for patients.

Tech ID/UC Case

22468/2012-063-0

Related Cases

2012-063-0

国家/地区

美国