Genomic Predictor of Kidney Cancer Prognosis and IL-2 Treatment Response
- 技术优势
- CA9 SNP pre-screening of patients with RCC prior to IL-2 intervention helps decrease the incidence of unwarranted treatment and the associated adverse side-effects for low-responders Integration of this SNP into various assays by pharmaceutical companies during clinical trials allows for the identification and validation of drug targets for RCC
- 技术应用
- For the determination of a CA9 SNP associated with improved overall survival from RCC and a greater likelihood of response to IL-2 therapy
- 详细技术说明
- Researchers at UCLA have identified a SNP in CA9 that acts as a biomarker of survival from renal cell carcinoma (RCC). Additionally, this SNP serves as an independent prognostic factor of positive response to IL-2 based immunotherapy of RCC.
- *Abstract
-
UCLA investigators have identified a single nucleotide polymorphism (SNP) for use as a biomarker for the prediction of overall survival and likelihood of response to interleukin-2 treatment in patients with kidney cancer.
- *IP Issue Date
- Jul 15, 2014
- *Principal Investigation
-
Name: Arie Belldegrun
Department:
Name: Allan Pantuck
Department:
- 附加资料
- Patent Number: US20110262391A1
Application Number: US13122553A
Inventor: Belldegrun, Arie S. | Pantuck, Allan J.
Priority Date: 8 Oct 2008
Priority Number: US20110262391A1
Application Date: 21 Jun 2011
Publication Date: 27 Oct 2011
IPC Current: A61K003820 | A61P003500 | A61P003504 | A61P003704 | C07H002104 | C12Q000168
US Class: 4240852 | 43500611 | 53602431
Assignee Applicant: The Regents of the University of California
Title: CA9 GENE SINGLE NUCLEOTIDE POLYMORPHISMS PREDICT PROGNOSIS AND TREATMENT RESPONSE OF METASTATIC RENAL CELL CARCINOMA
Usefulness: CA9 GENE SINGLE NUCLEOTIDE POLYMORPHISMS PREDICT PROGNOSIS AND TREATMENT RESPONSE OF METASTATIC RENAL CELL CARCINOMA
Summary: The method is useful for providing prognosis and treating renal cell cancer in human, where the cancer is metastatic renal cell cancer (MRCC) (all claimed). Test details are described but no results given.
Novelty: Providing prognosis for renal cell cancer in human, comprises obtaining sample comprising carbonic anhydrase IX nucleic acid, detecting presence or absence of single nucleotide polymorphism1 and providing prognosis
- 主要类别
- 诊断/治疗
- 细分类别
- 癌症/肿瘤
- 申请号码
- 8778608
- 其他
-
State of Development
Researchers have analyzed the CA9 gene-coding region and CAIX protein expression in kidney cancer patients to correlate SNPs with patient survival and response to IL-2 treatment. A SNP has been identified and patients with this polymorphism showed improved overall survival and a greater likelihood of response to IL-2.
Background
Renal cell carcinoma is the most common type of kidney cancer among adults, with 31,000 new cases and 12,000 deaths reported annually in the US alone. The disease is often asymptomatic until it has advanced far beyond a curative point, and thus the median survival time is low. Traditionally, for patients whose tumors are within range, surgery is the preferred treatment and has a 90% cure rate. Once the RCC has metastasized, alternative therapies such as interleukin-2 (IL-2) intervention become necessary. This therapy, though incredibly effective in a limited number of patients, is associated with high toxicity and low response rates overall. Previous studies have indicated that CAIX, the protein product of the carbonic anhydrase 9 (CA9) gene, is not expressed in benign organs and tissues but highly expressed in clear cell RCC. Expression of CAIX correlates with better prognosis and response to IL-2 therapy, but it would be advantageous to identify a single nucleotide polymorphism (SNP) biomarker in the coding region of CA9 to determine if DNA variants exist among patients that might effectively predict a patients response to IL-2 treatment.
Related Materials
Tech ID/UC Case
20377/2008-799-0
Related Cases
2008-799-0
- 国家/地区
- 美国
