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Production of Glutamic Acid Decarboxylase and Associated Polypeptides for Use in Clinical and Research Applications

详细技术说明: The vast majority of Type 1 diabetes (T1D) patients have sera which contain auto-antibodies and T cells reactive to glutamic acid decarboxylase (GAD) and/or peptide fragments of GAD. The present UCLA invention involves the cloning and production of GAD polypeptides for use in detection of autoantibodies and T cells reactive to GAD in biological samples. This method, therefore, may be developed into antibody and T cell-based diagnostic kits for identifying individuals at risk of developing T1D and to distinguish late onset T1D patients from Type II diabetes patients. Furthermore, the invention may also be used for purposes of screening drugs, such as those that alter GAD function, and for generation of polyclonal and monoclonal antibodies which, in turn, can be used diagnostically to detect GAD. Please see http://techtransfer.universityofcalifornia.edu/NCD/20095.html for diagnostic and therapeutic strategies for IDDM based on TH1 and TH2 responses.

*Principal Investigation: Name: Mark Erlander
Department:

Name: Daniel Kaufman
Department:

Name: Allan Tobin
Department:

附加资料: Patent Number: US6682906B1
Application Number: US1990586536A
Inventor: Tobin, Allan J. | Erlander, Mark G. | Kaufman, Daniel L.
Priority Date: 21 Sep 1990
Priority Number: US6682906B1
Application Date: 21 Sep 1990
Publication Date: 27 Jan 2004
IPC Current: A61K003851 | A61K005100 | A61P000310 | A61P002102 | A61P003702 | C12N000121 | C12N000988 | C12N001100 | C12N001509 | C12N001560 | C12Q0001527 | C12Q000168 | G01N003353 | G01N0033564 | G01N0033573 | A61K003800 | C12R000101
US Class: 4350691 | 4350693 | 435232 | 4352523 | 4353201 | 435325 | 5360232 | 5360235
Assignee Applicant: The Regents of the University of California
Title: Cloned glutamic acid decarboxylase
Usefulness: Cloned glutamic acid decarboxylase
Novelty: Novel cDNA encoding GAD65 polypeptide used to produce GAD65 for therapeutic and diagnostic application in insulin-dependent diabetes mellitus patients

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