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Generation Of Human Ips Cells By A Synthetic Self-Replicative Rna

详细技术说明: The generation of human induced Pluripotent Stem (iPS) cells holds great promise for development of stem cell therapies to treat a wide range of human diseases. However, the generation of iPS cells in the absence of integrative DNA vectors remains problematic. UCSD researchers have developed a simple, iPS generation approach to express reprogramming factors. Introduction of the vector into human fibroblasts results in the efficient generation of iPS cells with all the hallmarks of stem cells, including cell surface markers, global gene expression profiles and in vivo pluripotency to differentiate into all three germ layers.

*Principal Investigation: Name: Steven Dowdy
Department:

Name: Naohisa Yoshioka
Department:

附加资料: Patent Number: WO2013177133A3
Application Number: WO2013US41980A
Inventor: DOWDY, Steven, F. | YOSHIOKA, Naohisa
Priority Date: 21 May 2012
Priority Number: WO2013177133A3
Application Date: 21 May 2013
Publication Date: 20 Mar 2014
IPC Current: C12N001540 | C12N0005074 | C12N000510 | C12N001585
Assignee Applicant: The Regents of the University of California
Title: GENERATION OF HUMAN IPS CELLS BY A SYNTHETIC SELF- REPLICATIVE RNA | GÉNÉRATION DE CELLULES IPS HUMAINES PAR UN ARN DE SYNTHÈSE AUTO-RÉPLICATIF
Usefulness: GENERATION OF HUMAN IPS CELLS BY A SYNTHETIC SELF- REPLICATIVE RNA | GÉNÉRATION DE CELLULES IPS HUMAINES PAR UN ARN DE SYNTHÈSE AUTO-RÉPLICATIF
Summary: For producing stem cell (claimed) useful for treating disease e.g. cancer, neoplasm, injury, viral infection, diabetes.
Novelty: New alphavirus replicon RNA comprising non-structural replicase domain from alphavirus and non-alphavirus heterologous sequence encoding factors for inducing the generation of pluripotent stem cells for treating disease e.g. cancer

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