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Polypeptide And DNA Immunization Against Coccidioides Spp. Infections

详细技术说明

Researchers at the University of California, San Diego have patented the use of novel Coccidioides-specific antigens, polypeptides, and the nucleotide sequences that encode them as immunogenic antigens for a preventative or therapeutic vaccine for coccidioidomycosis, or for detection of immune responses in individuals infected by Coccidioides spp (e.g. C. posadasii or C. immitis).

*Abstract

Coccidioidomycosis, otherwise known as the San Joaquin Valley Fever, is a fungal respiratory disease of humans and wild and domestic animals which is endemic to southwestern United States, northern Mexico, and numerous semiarid areas of Central and South America. Infection occurs by inhalation of airborne spores produced by the saprobic phase of Coccidioides spp. which grows in alkaline desert soil. C. immitis was the first described species, and is now becoming known as the Californian species. The C. posadasii species was recently defined, and was previously recognized as the non-Californian population of C. immitis. It is estimated that 100,000 new cases occur annually within the regions of the United States between southwest Texas and southern California, where the disease is endemic. Immunocompromised patients are at high risk to contract disseminated coccidioidomycosis. African-Americans and Asians are genetically predisposed to development of the potentially fatal, disseminated form of the respiratory disease.

*IP Issue Date

Aug 28, 2007

*Principal Investigation

Name: Garry Cole

Department:

Name: Chiung-Yu Hung

Department:

Name: Theo Kirkland III

Department:

Name: Theo Kirkland III

Department:

Name: Kalpathi Seshan

Department:

Name: Jin Xue

Department:

Name: Jieh-Juen Yu

Department:

附加资料

Patent Number: US7262027B2
Application Number: US2004794287A
Inventor: Cole, Garry T. | Yu, Jieh Juen | Xue, Jianmin | Hung, Chiung Yu | Seshan, Kalpathi R. | Kirkland, III, Theo N.
Priority Date: 14 Mar 2003
Priority Number: US7262027B2
Application Date: 3 Mar 2004
Publication Date: 28 Aug 2007
IPC Current: C12P002106 | C07H002102 | C07H002104 | C07K001437 | A61K003900
US Class: 4350691 | 4352523 | 4352541 | 43525411 | 4353201 | 5360237 | 5360241 | 5360242
Assignee Applicant: Medical College of Ohio,Toledo | The Regents of the University of California | United States of America Represented by the Department of Veterans Affairsshington
Title: Polypeptide and DNA immunization against Coccidioides spp. infections
Usefulness: Polypeptide and DNA immunization against Coccidioides spp. infections
Summary: The composition and methods are useful for generating an immunological response in an individual, or for diagnosing, preventing or treating Coccidioides spp. infection and diseases states associated with the infection.
Novelty: New isolated nucleic acid molecules and polypeptides for generating an immune response in an individual, or for diagnosing, preventing or treating Coccidioides spp. infection and diseases states associated with the infection

主要类别

生物医学

细分类别

病原

申请号码

7262027

其他

Intellectual Property Info

U.S. Patent No. 7,262,027 - POLYPEPTIDE AND DNA IMMUNIZATION AGAINST COCCIDIOIDES SPP. INFECTIONS, Issue date: 28Aug2007.

Tech ID/UC Case

22460/2003-F16-0

Related Cases

2003-F16-0

国家/地区

美国