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New Method for Imaging Ventilation and Perfusion in the Lung Using MRI

技术应用

This novel technology provides unprecedented abilities to evaluate mechanisms of lung disease, injury, response to treatment and repair, and to screen populations of patients at risk of developing lung disease, and to monitor response to treatment in those already afflicted.

详细技术说明

UC San Diego researchers have developed a fully quantitative non-contrast proton MRI technique to measure alveolar ventilation (VA) and perfusion (Q) and VA/Q matching in the lung. The technology provides the ability to measure spatial VA/Q on a voxel by voxel basis on a standard 1.5 T clinical scanner. Furthermore, concerns about contrast injection and/or radiation hazard are completely eliminated, which would be especially important where repeated evaluation would be desirable.

*Abstract

Virtually all lung disease is characterized to some extent by disruption of alveolar ventilation (VA) and perfusion (Q) (VA/Q) matching, resulting in gas exchange inefficiency. The only fully quantitative technique considered to be the “gold-standard” at the moment is MIGET (multiple inert gas elimination technique), which quantifies the overall distribution of ventilation or perfusion as a function of VA/Q ratio. However, MIGET is technically very demanding, highly invasive, and does not provide spatial information.

*IP Issue Date

Sep 5, 2017

*Principal Investigation

Name: Richard Buxton

Department:

Name: Matthew Cronin

Department:

Name: Susan Hopkins

Department:

Name: Rui Pereira de Sa

Department:

Name: Gordon Prisk

Department:

Name: Rebecca Theilmann

Department:

附加资料

Patent Number: WO2012078823A3
Application Number: WO2011US63854A
Inventor: PRISK, Gordon, Kim | HOPKINS, Susan, Roberta | BUXTON, Richard, Bruce | PEREIRA DE SA, Rui, Carlos | THEILMANN, Rebecca, Jean | CRONIN, Matthew, Vincent
Priority Date: 7 Dec 2010
Priority Number: WO2012078823A3
Application Date: 7 Dec 2011
Publication Date: 27 Sep 2012
IPC Current: A61B0005055
Assignee Applicant: The Regents of the University of California
Title: MAGNETIC RESONANCE IMAGING OF VENTILATION AND PERFUSION IN THE LUNG | IMAGERIE PAR RÉSONANCE MAGNÉTIQUE PERMETTANT D'APPRÉCIER LA VENTILATION ET L'IRRIGATION DU POUMON
Usefulness: MAGNETIC RESONANCE IMAGING OF VENTILATION AND PERFUSION IN THE LUNG | IMAGERIE PAR RÉSONANCE MAGNÉTIQUE PERMETTANT D'APPRÉCIER LA VENTILATION ET L'IRRIGATION DU POUMON
Summary: Method for characterizing ventilation and perfusion in lung using MRI system (claimed).
Novelty: Method for characterizing ventilation and perfusion in lung, involves determining ventilation-perfusion ratio value that is product of ventilation value, air content value, inverse of perfusion value, and breathing frequency

主要类别

生物医学

细分类别

医学影像

申请号码

9750427

其他

State Of Development

To date researchers have studied fourteen subjects and have analyzed data from three of them. Efforts to develop the metrics for describing the data are ongoing.

IP STATUS

Patent pending.

Related Materials

Henderson AC, Sá RC, Theilmann RJ, Buxton RB, Prisk GK, Hopkins SR. The gravitational distribution of ventilation-perfusion ratio is more uniform in prone than supine posture in the normal human lung. J Appl Physiol. 2013 Apr 25. [Epub ahead of print]

Tech ID/UC Case

21991/2010-320-0

Related Cases

2010-320-0

国家/地区

美国