Plasmonic Dark Field Microscopy
PDF microscopy promises to deliver unprecedented performance in terms of spatial resolution, optical contrast, and device miniaturization and versatility at low cost.
UC San Diego researchers have developed a new optical imaging technique referred to as “plasmonic dark field” (PDF) microscopy. Instead of the lenses, light stops, and mirrors of conventional dark field microscopy, PDF microscopy uses a “plasmonic condenser” (PC) to guide the sample illumination angle. In one embodiment, the PC is essentially comprised of a metallic structure that converts light into surface plasmons. Since surface plasmons exist only at the metal surface, they appear completely dark in the far field. Only when an object is brought in the near field of the metal surface will light couple into the far field to form a perfect dark field image. The invention also includes active plasmonic couplers that use media, e.g., luminescent materials that provide mechanisms for exciting surface plasmons in a metal layer. The PC devices can be fabricated using well-established processes. Proof-of-concept for the invention has been achieved by numerical simulations and experiments. In particular, a chip-scale integrated multilayered fluorescent active PC has been used to demonstrate the new imaging technique.
Inventor: Arienti, Kristen L. | Breitenbucher, James G. | Buzard, Daniel J. | Edwards, James P. | Hack, Michael D. | Lee-Dutra, Alice | Khatuya, Haripada
Priority Number: US20090281307A1
IPC Current: C07D040312 | A61K0031454 | A61K00314545 | A61K0031496 | C07D023518 | C07D040104 | C07D040112 | C07D040114
US Class: 540575 | 544370 | 546194 | 546199
Title: Benzoimidazole compounds
Usefulness: Benzoimidazole compounds
Summary: For treating allergy, asthma, chronic obstructive pulmonary disease, atherosclerosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, ulcerative colitis, psoriasis, scleroderma, autoimmune thyroid disease, immune-mediated diabetes mellitus, lupus, myasthenia gravis, autoimmune uveitis, autoimmune hemolytic anemia, temporal arteritis, Behcet's disease, autoimmune hepatitis, and autoimmune oophoritis.
Novelty: New benzoimidazole compound useful for treating or preventing disorders and conditions mediated by histamine receptor e.g. inflammation, atherosclerosis, rheumatoid arthritis
化工/材料
化工/材料应用
9304234
Related Materials Tech ID/UC Case 21345/2009-289-0 Related Cases 2009-289-0
美国
