New Surface for Accelerated Cartilage Cell Growth
This biocompatible material can be used to coat the surface of orthopedic implants to permit a stronger bond with tissue as well as accelerate healing for joint replacements, resulting in shorter recovery times for patients. It may also reduce failure rates for such surgeries. Growth factors or other molecules, such as DNA or small molecule drugs, may be loaded into the nanostructure to promote the growth of cells. For cell culture applications, wafers of the nano-structured material can be inserted into cell culture plates or flasks for accelerated growth of cells.
Researchers at UC San Diego have developed a nanotube surface on titanium oxide (TiO2) that markedly accelerates the growth of cells. This biocompatible material can be used to coat the surface of orthopedic implants to permit a stronger bond with bone as well as accelerate healing. Early experimental results with cells in culture show strong cell adhesion with significantly enhanced formation of cells and associated growth. Economical and convenient fabrication of the nano-structured substrate material has been demonstrated in the laboratory.
Patent Number: US20110159070A1
Application Number: US2010997689A
Inventor: JIN, Sungho | Oh, Seunghan | Brammer, Karla
Priority Date: 3 Jul 2008
Priority Number: US20110159070A1
Application Date: 9 Mar 2011
Publication Date: 30 Jun 2011
IPC Current: A61L002754 | A61K000900 | A61K0009127 | A61K000970 | A61K00317088 | A61K003512 | A61K003802 | A61K003818 | A61K003822 | A61K004800 | A61L002738 | A61P001904 | A61P001908 | A61P004300 | B23K001500 | B23K002620 | B23K003102 | C12N0005077 | C23F000104 | H05B000602 | B82Y000500 | B82Y003000 | B82Y004000
US Class: 424423 | 216041 | 21912114 | 21912164 | 219635 | 228174 | 4240937 | 424400 | 424443 | 424450 | 435395 | 5140011 | 5140081 | 5140088 | 5140089 | 5140091 | 5140096 | 514044R | 977762 | 977810 | 977888 | 977900 | 977901 | 977906 | 977915
Assignee Applicant: The Regents of the University of California
Title: BIOMATERIALS AND IMPLANTS FOR ENHANCED CARTILAGE FORMATION, AND METHODS FOR MAKING AND USING THEM
Usefulness: BIOMATERIALS AND IMPLANTS FOR ENHANCED CARTILAGE FORMATION, AND METHODS FOR MAKING AND USING THEM
Summary: For stimulating cell growth, cartilage growth and/or bone deposition; for stimulates chondrocyte growth, maintenance and/or differentiation; for restoration, restructuring or repair of cartilage tissue in a thumb, a fingers, a wrist, an elbow, a shoulder, a hip, a knee, an ankle, a foot, a toe, an inter-vertebral disc of the spinal cord or a rib cage, or a nose or an ear, by in vivo, in vitro, or ex vitro implantation; or to replace damaged, infected, aged, or diseased cartilage caused by various diseases such as arthritis, osteoarthritis, isolated femropatellar osteoarthritis, rheumatoid arthritis, chronic or systemic autoimmune disorder, lupus, or other autoimmune diseases, osteonecrosis of the joint, or septic arthritis caused by joint infection; the product of manufacture is applied in vivo as a patch bone implant piece for bone repair (claimed).
Novelty: Product of manufacture e.g. a cartilage or bone growth-enhancing product comprises e.g. nanostructures comprising a nanotube, nanowire, nanopore, or nanopillar surface configuration on a titanium or its alloy; chondrocyte; or stem cells
生物医学
医药成分
9623151
State Of Development Patents pending Tech ID/UC Case 20603/2009-001-0 Related Cases 2009-001-0, 2005-225-1, 2005-225-2
美国
