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A Macromolecular Carrier for Medical Imaging and Diagnostics

详细技术说明: A UCSD researcher has developed a new macromolecular carrier having hundreds of leashes for readily attaching imaging agents and substrates. The attached substrate directs the carrier to specific tissues so that the attached imaging agent can affect its function in a tissue specific manner. When suitably derivatized, the carrier can be used in a tissue-specific manner for magnetic resonance imaging, computer tomographic imaging or scintigraphic imaging. This technology has been shown to exhibit excellent tissue-specific delivery of payload as demonstrated in animals and humans, is inexpensive to manufacture, and is non-toxic to humans. It has also been shown in animal tests to be a CT blood pool contrast agent with long intra-vascular dwell time. The patent - US 6,409,990 - is available for licensing for use in certain tissue types and imaging methods.

附加资料: Patent Number: US6409990B1
Application Number: US2000569466A
Inventor: Vera, David R.
Priority Date: 14 May 1999
Priority Number: US6409990B1
Application Date: 12 May 2000
Publication Date: 25 Jun 2002
IPC Current: A61K004720 | A61K004736 | A61K004742 | A61K004748 | A61K004900 | A61K004912 | A61K004914 | A61K005100 | A61K005106
US Class: 42400935 | 4240091 | 4240093 | 424009351 | 4240094 | 42400943 | 514054 | 514058
Assignee Applicant: The Regents of the University of California
Title: Macromolecular carrier for drug and diagnostic agent delivery
Usefulness: Macromolecular carrier for drug and diagnostic agent delivery
Summary: (I) is used for delivery of drugs, substrates, imaging agents or other diagnostic agents to specific cell tissues. It can be used for delivery of antiviral drugs, immunomodulatory drugs, anticancer drugs or DNA (for gene therapy). It is especially useful in CT methods, MRI methods or methods for sentinel node imaging (claimed) in diagnosis of cardiovasculature and/or tumors.
Novelty: New macromolecular carriers, which can carry a high density of drugs or contrast substrates, have low levels of cross-linking and are useful in diagnosis of tumors

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