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Methods to Preserve Distinctive Characteristics of Engineered Articular Cartilage

技术优势: This method is relatively simple and cost-effective, and could be easily scaled-up to produce large quantities of engineered tissue.

技术应用: The synthetic articular cartilage tissue produced using these methods can be used for any medical condition that would require a cartilage replacement. For example, it can be surgically implanted for the repair of focal cartilage defects or for the complete resurfacing of a degenerate or arthritic joint.

详细技术说明: UC San Diego researchers have developed a method of tissue engineering that preserves the regional distinctions within articular cartilaginous tissue. This heterogeneous tissue has a considerable advantage over other synthetic cartilage in that it more closely resembles natural tissue, retaining many if not all of the original biological functions. Biochemical, immunohistochemical, and biomechanical analyses have verified that articular cartilage generated in this fashion retains its biological properties to a much greater degree than tissues synthesized via earlier procedures.

*Principal Investigation: Name: Travis Klein
Department:

Name: Kelvin Li
Department:

Name: Koichi Masuda
Department:

Name: Robert Sah
Department:

Name: Barbara Schumacher
Department:

Name: Eugene Thonar
Department:

附加资料: Patent Number: US7476257B2
Application Number: US2002244035A
Inventor: Sah, Robert L. | Li, Kelvin W. | Klein, Travis J. | Schumacher, Barbara L. | Masuda, Koichi | Thonar, Eugene J-M. A.
Priority Date: 15 Sep 2001
Priority Number: US7476257B2
Application Date: 13 Sep 2002
Publication Date: 13 Jan 2009
IPC Current: A61F000228 | A61L002700 | A61F000202 | A61K003532 | A61L002738 | C12N0005077 | A61K003512
US Class: 62302372 | 4240937 | 424422 | 62301111
Assignee Applicant: Rush University Medical Center,Chicago | The Regents of the University of California
Title: Methods to engineer stratified cartilage tissue
Usefulness: Methods to engineer stratified cartilage tissue
Summary: In surgical restoration of articular cartilage; stimulation of fibrocartilaginous repair; osteochondral grafting; autologous chondrocyte implantation; and to replace or repair natural cartilage defects by implanting the construct into a joint. Also useful in diagnosing different pathological states in cartilage tissue, including physical injury and disease state, such as rheumatoid arthritis.
Novelty: Cultured, stratified cartilage tissue useful in cartilage repair comprises engineered, cohesive cartilage construct containing cartilage layers having chondrocytes with phenotype of chondrocytes of natural cartilage

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