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Novel Method to Inhibit Tumor Growth & Other Neovascular Diseases

详细技术说明

Bone marrow-derived stem cells are known to contribute to the repopulation of tissues undergoing repair. A mechanism by which the emigration of endothelial precursor cells from the circulation to sites of angiogenesis has recently been elucidated by researchers at UCSD. Increased understanding of this mechanism has identified a target for the modulation of stem cell trafficking. Peptide, antibody or small molecule antagonists of the target may inhibit bone marrow-derived stem cells from entering tissues and from participating in tumor growth, atherosclerosis, restenosis and other neovascular diseases such as arthritis and psoriasis. Conversely, homing of stem cells to endothelium can be stimulated allowing enhancement of angiogenesis in ischemic disease, muscle repair and nerve repair. Additionally, the target provides a method to isolate stem cells from tissues such as bone marrow or peripheral blood so that they can be expanded and used for therapeutic applications such as the treatment of damaged heart tissue or repair of congenital muscle defects.

*Abstract

None

*IP Issue Date

Aug 2, 2016

*Principal Investigation

Name: Judith Varner

Department:

附加资料

Patent Number: US20090130124A1
Application Number: US2003573944A
Inventor: Varner, Judith A.
Priority Date: 29 Sep 2003
Priority Number: US20090130124A1
Application Date: 14 Mar 2007
Publication Date: 21 May 2009
IPC Current: A61K0039395 | A01N000102 | C07K001628 | C12N000506 | G01N003350 | G01N003353 | G01N0033566 | G01N003368
US Class: 4241721 | 4241301 | 435002 | 4350071 | 435377 | 435378 | 436501
Title: Method for altering hematopoietic progenitor cell adhesion, differentiation, and migration
Usefulness: Method for altering hematopoietic progenitor cell adhesion, differentiation, and migration
Summary: The methods are useful for altering the level of hematopoietic progenitor cell adhesion to target tissue. The agent, compound and methods are useful for treating non-angiogenic diseases or angiogenic diseases, e.g. neoplasm, diabetic retinopathy, psoriasis, gingivitis, rheumatoid arthritis, osteoarthritis, or inflammatory bowel disease.
Novelty: Altering the level of hematopoietic progenitor cell adhesion, useful for treating non-angiogenic or angiogenic diseases, comprises treating the cells and the target tissue with the agent

主要类别

生物医学

细分类别

生物工程

申请号码

9403908

其他

Tech ID/UC Case

19607/2004-076-0

Related Cases

2004-076-0

国家/地区

美国