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Methods for Reduction of Proteotoxity Associated Diseases

技术应用: Treatment of disorders associated with protein misfolding and/or aggregationDrug screening

*Abstract: Proteotoxicity-associated diseases and disorders are characterized by increased aggregation of certain proteins or amino acids inside and/or outside of the cell. Exemplary proteotoxicity-associated diseases include, but are not limited to, Alzheimer's, Parkinsons, and Huntington’s, macular degeneration and spinal and bulbar muscular atrophy. Many of these proteotoxicity-associated diseases are also associated with aging.

UC Berkeley researchers have developed a technology for reducing protein misfolding and/or aggregation in a cell. The present disclosure provides methods of treating diseases and disorders associated with protein misfolding and/or aggregation with active agents that inhibit carnitine palmitoltransferase or reduce the level of mitochondrial heat shock protein.

*Principal Investigation: Name: Andrew Dillin
Department:

Name: Hyun-Eui Kim
Department:

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