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Digital Separation For One-Step Hiv Viral Load Monitoring

技术优势: - First low-cost, portable and precise point-of-care solution for HIV viral load monitoring; significant improvements to current systems in time, equipment and labor- Data acquired comparable to data from a thermal cycler - Chip is able to catch early infection patients without a high viral concentration- Portable and power-free; ideal for point-of-care or low resource settings

技术应用: - Portable microfluidic platforms for quantitative nucleic acid amplification in one-step diagnostic assays- Portable chip can be adoptable to other diseases- Low cost HIV monitoring in economically challenged countries (e.g., Africa)- Low cost nucleic acid based quantitative telemedicine applications

详细技术说明: None

*Abstract: Quantitative molecular diagnostics such as HIV viral load monitoring is essential for follow-up testing of treated AIDS patients. Current FDA approved tests require multiple steps of sample preparation, 3-6 hours of assay time, highly trained technicians, costly equipment and centralized lab testing. Transportation of HIV specimens also risks degradation of the RNA target.

Berkeley researchers have developed a state-of-the-art technology for on-site one-step quantitative molecular diagnostics. As an application example, they demonstrated for the first time that digital separation technology can be used to detect HIV viral load in whole blood. The invention enables on-chip digital amplification analysis. On-chip HIV RNA detection from whole blood and quantitative nucleic acid detection can be performed in a one-step 30 minute process. The system is self-powered and the readout signal can be quantified by a smart phone.

This portable low cost technology (~$10/test, <$100 for smartphone based readout system) is much faster and requires significantly less manual operation than commercially available systems. It is envisioned to replace labor intensive and costly thermal cyclers (~$50/test, $30-70k for real-time thermal cyclers), thus enabling rapid and safe diagnosis for HIV patients and HIV/AIDS surveillance for those who normally do not have proper access to healthcare facilities. This platform technology may also be easily adopted for the detection of other diseases too.

*Principal Investigation: Name: Luke Lee
Department:

Name: Erh-Chia Yeh
Department:

其他

Additional Technologies by these Inventors

Tech ID/UC Case

23251/2013-143-0

Related Cases

2013-143-0

国家/地区: 美国

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