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Protein Microarray

*Abstract: This novel micro-sensor system is ideal for use in detection of disease-associated antigens as it is highly sensitive, specific, efficient, and can be used for a multitude of diagnostic purposes.

The premise of this unique sensor design is to rely on breaking of a pre-formed complex bound with an antibody via competitive interactions with an analyte (an immunogenic protein). In this strategy, the pre-established complex exhibits a lower binding constant. The sensor design will rely on the dissociation of the pre-formed complex with an antibody both as a means of achieving sensor selectivity and specificity, and as its signal transduction mode.

This technology holds several advantages:

? High sensitivity due to the unique intrinsic amplification method
? Fast detection using minute sample volumes
? Individual detection elements designed for specific disease-associated antigens
? Ideal for clinic or hospital where a large number of specific analyses are done

Patent Application Filed

附加资料: Patent Number: US20070231796A1
Application Number: US2005238635A
Inventor: Majda, Marcin
Priority Date: 17 Sep 2003
Priority Number: US20070231796A1
Application Date: 28 Sep 2005
Publication Date: 4 Oct 2007
IPC Current: C12Q000168 | C12M000300 | G01N003353
US Class: 43500616 | 435006 | 4350071 | 4352872 | 977924
Assignee Applicant: The Regents of the University of California
Title: Sensor and method for detection of a target substance
Usefulness: Sensor and method for detection of a target substance
Summary: The sensor is useful for determining in an analyte the presence of a target substance, preferably antigen or antibody (claimed).
Novelty: New sensor comprising molecular tethers attached to a sensor surface and a measurement system, useful for determining in an analyte the presence of a target substance, preferably antigen or antibody

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