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Novel Corticotropin-releasing Hormone Analogs And Uses Thereof

技术优势: This invention relates to peptide analogs of corticotropin-releasing hormone and their use for treatment of proliferative disorders of the skin and other tissues.

技术应用: This invention relates to peptide analogs of corticotropin-releasing hormone and their use for treatment of proliferative disorders of the skin and other tissues.

*Abstract: This invention relates to peptide analogs of corticotropin-releasing hormone. Particularly, the invention provides analogs wherein the 38.sup.th amino acid from the N-terminus is D-Nle, i.e. [D-Nle.sup.38 ]-CRH peptide.

*Principal Investigation: Name: Kurt Carlson
Department:

Name: Edward Wei
Department:

附加资料: Patent Number: US6849600B2
Application Number: US2002106588A
Inventor: Wei, Edward T. | Carlson, Kurt W.
Priority Date: 25 Mar 2002
Priority Number: US6849600B2
Application Date: 25 Mar 2002
Publication Date: 1 Feb 2005
IPC Current: C07K0014575 | A61K003800
US Class: 5140108 | 514012 | 5140211 | 530300 | 530317 | 530324 | 930021 | 930270 | 514002 | 514009
Assignee Applicant: The Regents of the University of California,Berkeley
Title: Corticotropin-releasing hormone analogs
Usefulness: Corticotropin-releasing hormone analogs
Summary: The peptide is useful for treating proliferative disorders (e.g. melanoma) of the skin or other tissue in human (claimed). The peptide is also useful for treating other cancers such as uterine cancer, and other diseases such as inflammatory dermatoses, psoriasis, premalignant lesions e.g. lentigo maligna, actinic keratosis, eczema, alopecia areata, hypertrichosis and keloids.
Novelty: Peptide useful for treating e.g. melanoma, psoriasis, or eczema comprises a member of the corticotropin-releasing hormone superfamily

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