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Bioactive Borate Materials for Use in Mammals

*Abstract: Borate glass compositions which are biocompatible and bioactive in a mammal have been developed for biological applications. These glasses react substantially faster with the body fluids than silicate based bioactive glasses to form an initial amorphous calcium-rich phosphate material which eventually becomes hydroxyapatite (HA).Borate glasses have several important advantages for biological use such as their ease of preparation, ability to be made into glass particulates, microspheres or fibers at relatively low temperatures without crystallization, and, particularly, their biocompatibility and high degree of bioactivity. Self-bonded scaffolds of borate glass fibers react rapidly with body fluids such that they have lost 60% of their initial weight and are completely impregnated with vascularized soft tissue in less than 4 weeks.

*Principal Investigation: Name: Steven Jung, PhD Candidate at Missouri S&T (former student)
Department:

Name: Delbert Day, Curators' Professor Emeritus
Department:

Name: Roger Brown, Professor Emeritus
Department:

附加资料: Inventor: Day, Delbert E. | Erbe, Erik M. | Richard, Marina | Wojcik, Joshua A.
Priority Number: US6709744B1
IPC Current: C03C000314 | C03C000319 | C03C000400 | C03C001000
US Class: 428403 | 42400129 | 424489 | 424601 | 424660 | 424677 | 424696 | 428404 | 428406 | 428407
Assignee Applicant: The Curators of the University of Missourilumbia | Vita Licensing Inclmington
Title: Bioactive materials
Usefulness: Bioactive materials
Summary: Used as bioactive material, i.e. silica-free glass material, e.g. ceramic, glass, glass-ceramic or partially crystalline (claimed) used in vivo.
Novelty: Bioactive material, i.e. silica-free glass material, e.g. ceramic used in vivo, comprises sodium oxide, calcium oxide, phosphorus oxide, and barium oxide

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