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Novel Sodium Channel Blockers

标题

CLUSTER BORON COMPOUNDS AND USES THEREOF

详细技术说明

None

*Abstract

A new family of voltage-gated sodium channel blockers has been synthesized that potentially provides therapeutic alternatives to currently used analgesics, antiarrhythmics, anticonvulsants, and antidepressants. The sodium channel is an integral part of nerve and cardiac cell conduction pathways. The small, structurally unique, sodium channel blockers described here differ from current sodium channel blockers such as lidocaine. Preliminary studies of the physiology and neurobehavior of these compounds show that they are functional sodium channel blockers. In cell expression studies these compounds block brain type sodium channels in a manner typical of local anesthetics. These compounds provide analgesia after sciatic nerve injection and have a longer duration of action than lidocaine in vivo. Importantly, their unique structures make them poised to show selectivity among sodium channel subtypes in excitable cells. POTENTIAL AREAS OF APPLICATION:• Inflammation, neuropathic pain, abnormal cardiac rhythms, seizures and depressionMAIN ADVANTAGES OF INVENTION:• Greater hydrophobicity and longer duration of analgesia than lidocaine• Evidence for selective sensory vs. motor block• Unique structures provide basis for targeting specific voltage-gated sodium channel subtypesSTAGE OF DEVELOPMENT:• Preclinical PATENT STATUS:• PCT/US2012/055181CONTACT INFO:Paul Hippenmeyer, Sr. Licensing & Business Development AssociateOffice of Technology Management and Industry Relations Email: hippenmeyerp@missouri.edu Phone: 573-882-0470

*IP Issue Date

Dec 22, 2015

*IP Publication Date

Mar 12, 2015

*Principal Investigation

Name: George Kracke, Associate Professor

Department:

Name: Yulia Sevryugina, Assistant Professor of Inorganic Chemistry

Department:

Name: Marion Hawthorne

Department:

申请日期

Mar 14, 2014

申请号码

9,217,002

其他

国家/地区

美国